ID   A0A1I7XKP2_HETBA        Unreviewed;       148 AA.
AC   A0A1I7XKP2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Thymidylate synthase {ECO:0000256|ARBA:ARBA00015931};
DE            EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
OS   Heterorhabditis bacteriophora (Entomopathogenic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heterorhabditidae;
OC   Heterorhabditis.
OX   NCBI_TaxID=37862 {ECO:0000313|Proteomes:UP000095283, ECO:0000313|WBParaSite:Hba_18343};
RN   [1] {ECO:0000313|WBParaSite:Hba_18343}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004992}.
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DR   AlphaFoldDB; A0A1I7XKP2; -.
DR   WBParaSite; Hba_18343; Hba_18343; Hba_18343.
DR   UniPathway; UPA00575; -.
DR   Proteomes; UP000095283; Unplaced.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 3.
DR   InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR   InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR   InterPro; IPR000398; Thymidylate_synthase.
DR   PANTHER; PTHR11548:SF2; THYMIDYLATE SYNTHASE; 1.
DR   PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR   Pfam; PF00303; Thymidylat_synt; 3.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          8..45
FT                   /note="Thymidylate synthase/dCMP hydroxymethylase"
FT                   /evidence="ECO:0000259|Pfam:PF00303"
FT   DOMAIN          45..80
FT                   /note="Thymidylate synthase/dCMP hydroxymethylase"
FT                   /evidence="ECO:0000259|Pfam:PF00303"
FT   DOMAIN          80..148
FT                   /note="Thymidylate synthase/dCMP hydroxymethylase"
FT                   /evidence="ECO:0000259|Pfam:PF00303"
SQ   SEQUENCE   148 AA;  16995 MW;  7C19F2AC49C3C8F8 CRC64;
     MENNDEYKYL EQIKEILENG KERTDRTGVG TISIFGMQNR YCLRDDLKQM ALPPCHTLCQ
     FFVQDGELSC QLYQRSGDMA GELVHTLGDA HIYKNHIDAL KAQLERTPCA FPTVHFSEEI
     SEIDDFTSEK IILKNYCPQA PIKMDMAV
//