ID A0A1I7XS05_HETBA Unreviewed; 589 AA.
AC A0A1I7XS05;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Peptidase_M1 domain-containing protein {ECO:0000313|WBParaSite:Hba_20311};
OS Heterorhabditis bacteriophora (Entomopathogenic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heterorhabditidae;
OC Heterorhabditis.
OX NCBI_TaxID=37862 {ECO:0000313|Proteomes:UP000095283, ECO:0000313|WBParaSite:Hba_20311};
RN [1] {ECO:0000313|WBParaSite:Hba_20311}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR634015-3};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR634015-3};
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DR AlphaFoldDB; A0A1I7XS05; -.
DR WBParaSite; Hba_20311; Hba_20311; Hba_20311.
DR Proteomes; UP000095283; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 2.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR034015; M1_LTA4H.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR45726:SF6; LEUK-A4-HYDRO_C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45726; LEUKOTRIENE A-4 HYDROLASE; 1.
DR Pfam; PF01433; Peptidase_M1; 2.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 2.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR634015-3};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PIRSR:PIRSR634015-3}.
FT TRANSMEM 180..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..158
FT /note="Aminopeptidase N-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17900"
FT DOMAIN 218..320
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT DOMAIN 463..498
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT BINDING 224
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
SQ SEQUENCE 589 AA; 68249 MW; 3F5CD08644DBF9AB CRC64;
MIRDPATSSN YNQVTVTHYS LLWNVCFEEK RISGKIEISL KCLQSTDRVI FDGRCLNIES
VTLNGEKLKF SEEPNDPLGQ KITISTPLLV EGMEIKLVID YRTASEASAL QFMPKELTTD
KKAPYLFSQC QAIHARSIMP CMDTPSVKST YDAKIRSCCP SFNVSFRWYG KSVSNICDSY
SAGTLVLSII LSVIYITALN VFFIGNYTHF ITGCVLFNGF RLNEGFTVFL ERKIHGKING
ELERQFESER GYDETLTSAV KTFGHDHEFT KLVQDQRGID PDDAFSSVPY EKGSAFLIVI
EQILGESGRF EQFLQMYIKN GGDRILKFMK DILHIPTMIR FAYQSITTEV WKAELYSFFP
DKKSELDSID WNTWLYQPGM PPKPKMCQSH FRPKKDPCSC ANNHEVVVIH TAIKWDVYFQ
LKMLIGQATL TCKMIHKTDK ICQAIHARSI VPCMDTPSVK STYEAEAGDR SLVSVIAHEI
AHSWSGNLVT NSSWEHFWCT TYCFLTFTYF ISILNPFKAF PYNFKLVYIY IYIYIYIYIY
IYIYICFSEV FEEYLRDYLS VFAHKAIDSY QWKQHLYKYF HVSQQFKHE
//
