ID A0A1I7XTH3_HETBA Unreviewed; 766 AA.
AC A0A1I7XTH3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=SH3 domain-containing protein {ECO:0000313|WBParaSite:Hba_21049};
OS Heterorhabditis bacteriophora (Entomopathogenic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heterorhabditidae;
OC Heterorhabditis.
OX NCBI_TaxID=37862 {ECO:0000313|Proteomes:UP000095283, ECO:0000313|WBParaSite:Hba_21049};
RN [1] {ECO:0000313|WBParaSite:Hba_21049}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR AlphaFoldDB; A0A1I7XTH3; -.
DR WBParaSite; Hba_21049; Hba_21049; Hba_21049.
DR Proteomes; UP000095283; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11793; SH3_ephexin1_like; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845:SF5; EPHEXIN, ISOFORM D; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 97..303
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 338..461
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 472..533
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 19..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 87226 MW; F70E23276125DD1D CRC64;
MDQPLYQIYM MEEHEKLIDD VNSHDTTEEL ARADDSEERE RKIKSRRESS ASSDSGRGAD
CSTSASALTS NTSMRRERLI ASSHFGSQRS LWCELPEVIT SEASYLRSLN ILITHFMASQ
ELMGSKSSLS VITNAERKHL FSNIFAVRDC SERFVFQLSC RILICILSVY ILCGFRLLCD
LETRLEENLV LDDLCDFLVD HFEKNFDVYV KYCSNQVYQD RTLRRLKSEN NNFLSAVSRL
EADKQCQGLD MRSFLMLPMQ RVTRYPLLMY AIIDRLPIDS ERYKVASRAL NAANKVVREC
NEGARRMERT EQLLEVDRRL VYKDPDLKRI PLVSNSRHLV KRGPLVQLIE RRTKGILQAR
QKSRGLHIFL FSDIIMITKK RLNGTYECKD YAARRYVDVE PIEAGNTKIP SGALSSLTSC
PHLFICILMR NARGKHTELL FNADSETDRE RWLSAIRPPT SLNPEEKVYA EWDCPQAIAV
HNYSKNQDDE LDVQVGDTVN ILRKMPDGWF YGERTRDGAG GWFPSSYVQQ ILNDHVRANN
YRQRLRLIQM FYSVIAFFTI ALAYAQYDDL SIIQEVLDKS TVLPGQIASH FVSDLISNNI
VSNQTASSII PKHTTIPILP NKTGGSVLPS DIITNNVVSN QSTNTQKLTE NATLTDITLL
EKIIVSTESP STKSESSSSE LNEKEELVEL IKETSANVSE YTTTAGNEWT ENSTASIELG
TEKQLTTEKS IISTMETTIT PVDSEDSFFG MLKPDLATIY RRLFPF
//
