ID   A0A1I7Y480_9BILA        Unreviewed;       551 AA.
AC   A0A1I7Y480;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819};
OS   Steinernema glaseri.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC   Steinernema.
OX   NCBI_TaxID=37863 {ECO:0000313|Proteomes:UP000095287, ECO:0000313|WBParaSite:L893_g12563.t1};
RN   [1] {ECO:0000313|WBParaSite:L893_g12563.t1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC       number of specific mRNAs. Acts by directing the binding of methionyl-
CC       tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC       binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC       whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC       GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993}.
CC   -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC       {ECO:0000256|ARBA:ARBA00009573}.
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DR   AlphaFoldDB; A0A1I7Y480; -.
DR   WBParaSite; L893_g12563.t1; L893_g12563.t1; L893_g12563.
DR   Proteomes; UP000095287; Unplaced.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR011387; TIF2A.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR   PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   DOMAIN          221..408
FT                   /note="Translation initiation factor beta propellor-like"
FT                   /evidence="ECO:0000259|Pfam:PF08662"
FT   COILED          496..526
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   551 AA;  61405 MW;  2A457963048CED2D CRC64;
     MGENLLLAIR GSTGLFVRRG VTNPPNFVLL EEEESKTKTV RTFAFSNSGQ YFAYCDCNKT
     VVLEVASGRT VISEALPRTT NFAFSPRDRI CVTYEPYVIY GARTNDDNTP RQPLPNLRFW
     SLVDGRLLTT LVANKNASWR PQWTEDESTA VRLSGSELHV YKNNNFERFE SKLVLKNVQS
     FEISHGHGNH HLCCYIPGSG GQPAVVQLRK FDEKATLVGN KTFFKCDSVK MKWNLKGTAC
     IVMSLTDVDA ANKSYYGEST LYLMTTSGDS CLVNLDKQGP VYAVEWNPNG KEFTVCYGFM
     PARVCTFNLK GDVIWDNGTQ HVNELHYNRF GNILLVCGFG NISSGRMDFY NVDEKKLIVS
     IKVPNCTQFA WAPDGQHFVT AQTAPRLRFE NGYRIWHYTG KLISEVLYAE KEELAQILWR
     PLPSDALTKF KITELTAEQK AQAGLPVKNS AVNGSPAVAA GAVTKKTGYI PPHLRKANGA
     GALKPPGAAA VVKPAVSENE KKARNIQKKL DEIEKLKAKL EAGEVLQKNQ LAKMDKRDEY
     IAELEALKIS S
//