ID   A0A1I7YN10_9BILA        Unreviewed;       650 AA.
AC   A0A1I7YN10;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Neur_chan_LBD domain-containing protein {ECO:0000313|WBParaSite:L893_g18067.t1};
OS   Steinernema glaseri.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC   Steinernema.
OX   NCBI_TaxID=37863 {ECO:0000313|Proteomes:UP000095287, ECO:0000313|WBParaSite:L893_g18067.t1};
RN   [1] {ECO:0000313|WBParaSite:L893_g18067.t1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       {ECO:0000256|RuleBase:RU000687}.
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DR   AlphaFoldDB; A0A1I7YN10; -.
DR   WBParaSite; L893_g18067.t1; L893_g18067.t1; L893_g18067.
DR   Proteomes; UP000095287; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   CDD; cd18990; LGIC_ECD_GABAAR; 1.
DR   CDD; cd19049; LGIC_TM_anion; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945:SF564; LIGAND-GATED ION CHANNEL; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU000687};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU000687};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   CHAIN           18..650
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT                   /id="PRO_5022247621"
FT   TRANSMEM        499..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        534..553
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        565..586
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        619..640
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   DOMAIN          293..499
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
FT   DOMAIN          507..587
FT                   /note="Neurotransmitter-gated ion-channel transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF02932"
SQ   SEQUENCE   650 AA;  74769 MW;  3B7B7A96F40056CD CRC64;
     MSPFLIWLIF FLFTTACIRL TEKTAQSCTS VFLAWSHDQV KSAVCMLLVA AGNTCWELLL
     FVVLLPWFEH YAIQHLFHLF LCRCLQHYGD QLGSSEGEPG STLQSASSAS QALFEAGKCA
     SSSATDWKSI GIQYPYLRVS HERHTLHRGP QLEEEDGHQV FPAAAVPVRA HRHLHDHDVR
     VEQLPDERCC RLLLDLSRAQ VHRATCRRAS DHGHTVSDRN ELALRRWFPS AVSMPEHRPS
     WTSNLSVASQ LLCSSWLLTA VLVASLIPPS LAFLPSARQL ANAAEYCSND TDIIDYLLYG
     TALNYNRHQL PSNPVQVRIE LWIQEVTSVS ELTQDFEIDL YVNEFWEDPA LAYEVLRPCK
     GNLSFDYKMQ DNIWIPNTCF INSKSAQIHS SPFRNVFLMV FPNGSIWSCW RIKSRGPCVM
     DLAKFPMDMI SCLLTFESYN YNIKEVRMRW NEPTPVLLFK DIELPDFTMV NFSTHIVEAK
     YAAGYWDELT VTFVFKRRYG WYLLQGYIPT YLTIFISWIS FYLGPRAIPA RTMIGVNALL
     AMTFQFGNII RNLPRVSYIK AIDVWMLSGM TFVFASLIEL AVIGFLNRNE GRAEIKLRDL
     HKRKKKKTSC KLDSEKLDLY SRVAFPVVYS LFNVIYWVYY MGDVFSTEEK
//