ID   A0A1I7YQB7_9BILA        Unreviewed;       903 AA.
AC   A0A1I7YQB7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE            EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS   Steinernema glaseri.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC   Steinernema.
OX   NCBI_TaxID=37863 {ECO:0000313|Proteomes:UP000095287, ECO:0000313|WBParaSite:L893_g18630.t1};
RN   [1] {ECO:0000313|WBParaSite:L893_g18630.t1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001171};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   WBParaSite; L893_g18630.t1; L893_g18630.t1; L893_g18630.
DR   Proteomes; UP000095287; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd00063; FN3; 1.
DR   CDD; cd00064; FU; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 3.80.20.20; Receptor L-domain; 3.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   PANTHER; PTHR21662:SF19; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR   PANTHER; PTHR21662; UNCHARACTERIZED; 1.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF01030; Recep_L_domain; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          330..464
FT                   /note="Furin-like cysteine-rich"
FT                   /evidence="ECO:0000259|Pfam:PF00757"
FT   DOMAIN          480..579
FT                   /note="Receptor L-domain"
FT                   /evidence="ECO:0000259|Pfam:PF01030"
SQ   SEQUENCE   903 AA;  101201 MW;  337632CA68C783C9 CRC64;
     MCDSDNRFVL LLAGKQIHGE RESKSGKNHL SRCEEHPCRS IFIRSDPNKA YTTYSTNTTE
     WTAADYEKCT VIEGDVGICQ VAYINTPYLR FPNVREITGS LWIFETITNT TEWTAADYEK
     CTVIEGDVGI CQVAYINTPY LRFPNVPSPS VHGALPEVSN PSATFSPIFA SLAAKPSLCT
     SPSSSPITST SXXXXLTFGV ITDIKTDLMD SSGSCEIPIT SCRPKELPKE ASLSCTMVNN
     VTSCWNSESC QIECAHGIHY EGNVXXXALG LSKLTAIRNG GVRIKENDAL CTKNIDWNKL
     TFGVITDIKT DLMNSTGSCE SPITSCSSKK LPKGTSLSCT MVNNVTSCWN NERCQIGCDP
     YGQRCHEACF GGCEKVNDPT KCYSCQNVLY NGTCVDKCPP HLYTYMQRRC VTKEECNSMP
     PIQKEYFKAI HGKCDVECPE GYIQDENDKF RCRKCSGPCI RVCELNHVVN TVKKAMSLSK
     CNIIKGFLDI SLNVAPEEKL MEAFGNITEI RDYLVIRFTP AMRSLRLLPN LRKIHGHNVY
     DDRYALVASD NENLADLEPG RLEILNGTVM FTDNPKLCPW VIHRFLSAAN LTKKVDDADV
     SPFTNGDGVI CAKEDFYVNV TASYDFGFVL SWEPFXXXXA ANLTHKVDDA DVSPFTNGDG
     VICAKEDFHV NVTASYDFGF VLSWEPFDTS QMDKRQFFGY LIYYKNVSSP MEYVDRNSDR
     SDECSDSWHS AFFAEDWNHR VTHGFVSAQP DTYYAFYVEX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXREV VASSKKHDMI EITWKPPKNP RGTITHYQVS
     WNEEAKRVFL VGDGCSALTY QVVATSKKHD MIEITWKPPX XXAVVLRKII RVIEQQRSLL
     SVD
//