ID A0A1I7Z610_9BILA Unreviewed; 850 AA.
AC A0A1I7Z610;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Very low-density lipoprotein receptor {ECO:0000313|WBParaSite:L893_g23181.t1};
OS Steinernema glaseri.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC Steinernema.
OX NCBI_TaxID=37863 {ECO:0000313|Proteomes:UP000095287, ECO:0000313|WBParaSite:L893_g23181.t1};
RN [1] {ECO:0000313|WBParaSite:L893_g23181.t1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A1I7Z610; -.
DR WBParaSite; L893_g23181.t1; L893_g23181.t1; L893_g23181.
DR Proteomes; UP000095287; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 349..385
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 434..469
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 470..514
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 473..514
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 613..655
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 656..699
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 700..744
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 793..834
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DISULFID 88..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 100..115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 151..166
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 195..210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 237..252
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 279..294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 329..344
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 350..362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 357..375
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 369..384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 850 AA; 96095 MW; 8EF2CEFD84659959 CRC64;
MQSVRRAVFG SRRQEVESLR RRLERLSPTQ RERTVYLSTS DVLIGWKSYF AGHKPSRMII
RPLLFFALLA TAAAASEQCR EDQHMFECAN KKCIPKIWLC DGDNDCTDGS DETDCNPLQD
VKCNSIEFKC PVHEFNELKT PASCIPQSWL CDGEPDCPGR EDEHDCKNLT CKANTFACPA
FSSNTITCAP NSWKCDGQVD CNDGSDEKDC DDAKKCDKDS EFQCKKDHHC INSKWVCDGD
TDCLDGSDEE NCEKKDCTGD KLRFACKTNN FCIPVAWRCD GERDCLDSSD EQNCTAEERL
QHVVVHVNCT DAHFKCKSGN QCIQKGWVCD GEYDCHDLSD EEGCKRPDEC STDEFKCDLG
LCRPNSVRCN GIEDCLDGTD EINCSFENAE VFCNETQFEC PGKPRVCIDY KDMCRESKFD
CSKPVCQNVT QTHLCDADAD PNCRCRKSYT NKGFCQCAPG YKLNGRKCVD INECETIGIC
DQKCYNLPGS YECRCEHGYH LVQGPSEGVP SKCKANGSDP LLFLSNRVTI RKYDLVTKNY
NSLVTRLESA VAMDFWHKAK ALIWSDVAKE KIMICHMGQK STLNNIKECD DENVDLITDV
MTPDGLAVDW VHGLLFWTDT GHNQINVMNL TDRHRRTIVD TGLDEPRAIA VDPSNGVIFW
TDWGTSKIER AGMDGQNRVT IVSGDDVKWP NGLTLDIVSK RIYWADAKLK MISSSDYSGN
NIRVVLRDHR NLKHPFSLTV FEERLYWTDW EHDGVLTANK FNGKDISTIM SGVRGPMTVR
VYHELVQPEL PDKCAYHTCD QLCLPRSRIG NHSLQVPYSC LCSRDHKMEN GHCVNTSLAN
GTSTTFMFQH
//
