ID   A0A1I7ZEZ5_9BILA        Unreviewed;       641 AA.
AC   A0A1I7ZEZ5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Neur_chan_LBD domain-containing protein {ECO:0000313|WBParaSite:L893_g25777.t1};
OS   Steinernema glaseri.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC   Steinernema.
OX   NCBI_TaxID=37863 {ECO:0000313|Proteomes:UP000095287, ECO:0000313|WBParaSite:L893_g25777.t1};
RN   [1] {ECO:0000313|WBParaSite:L893_g25777.t1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A1I7ZEZ5; -.
DR   WBParaSite; L893_g25777.t1; L893_g25777.t1; L893_g25777.
DR   Proteomes; UP000095287; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 6.10.250.2810; -; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945:SF906; LIGAND-GATED ION CHANNEL; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        379..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        611..629
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          188..246
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
FT   DOMAIN          364..627
FT                   /note="Neurotransmitter-gated ion-channel transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF02932"
FT   REGION          110..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   641 AA;  73502 MW;  81014A3526FCF0B1 CRC64;
     MFKETWIYIT SLIFRAKSAS NTQQKAIYQP RSSGLDCGIR GAEEGAIGPT TTSDSSRNWF
     QSFDVDLYLY MSWQDPHLNH SGPGYVMVND EVVRQELWYV CGRSVNRSAR DPGPESFMSR
     TGLAPKTKQS GEARLGGVKV ARPLLRKRAL RSLPPRHRAQ FQFIHCARWH RRLFQQVGPA
     TKTNINPLRV TLNVACNLNL INYPMDRQNC YIRALSYAYI AKMVNITWFR SKPLLYNPEI
     GLPEFGITAI EPGYCNGTYR YAITEYSQKI GGSRHDGPLS ASCRQFQLSD GQHPSGAFHR
     LQPRPELHPD GTHRHHLMGL LLDRPPRRPG QGHAQLYDAR LADDSGEFRL GLRFMGPEGN
     GNGVRFSLPQ VSYAKAIDFW FGACMLFVFC ALLEFALVNS FMRKSEKYEK LSKKFAADRD
     DRVLPMSVSA LLRSHEKMQR ERKGSLFPVM NGIREYTNPL ARMSPAGRRR KFAARRASAR
     VKFDDESRRP NGNSFELKEK ARRKKGSFFE DDDKNRESNA LLDSLYDNLQ EKTPEKTDFG
     DDHTDLVDDD SPMLFRKSSS EDPEWAERTH VWSARPNPKR HSVAPNPELS EQYAEVSSMF
     SRRALNIDKS CRYVFPGLFI LFNFFYWTIY TRSANDFGDN L
//