ID A0A1I7ZM75_9BILA Unreviewed; 2318 AA.
AC A0A1I7ZM75;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=C2 DOCK-type domain-containing protein {ECO:0000313|WBParaSite:L893_g27693.t1};
OS Steinernema glaseri.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC Steinernema.
OX NCBI_TaxID=37863 {ECO:0000313|Proteomes:UP000095287, ECO:0000313|WBParaSite:L893_g27693.t1};
RN [1] {ECO:0000313|WBParaSite:L893_g27693.t1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR WBParaSite; L893_g27693.t1; L893_g27693.t1; L893_g27693.
DR Proteomes; UP000095287; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR CDD; cd11695; DHR2_DOCK_C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 702..867
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1819..2286
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1258..1274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2318 AA; 258164 MW; 57168E585399437A CRC64;
MRTKPSNAQC LLDYPSSRDA QLFPESKARL AAEPRGHRRP RGRGGAPPAE DLRPLRPCFR
QSRQEVGPSS DTVTPCFRVH EFPLDDIDVR VVHRDKITEP SVADNLSEVA VEPQIRDLIA
TYHDQFSLVQ RRHQQYSSAD AYIRMLMERP ILAQTLPRQS YELDVDVEAA KRAKRSASVV
EDQCPLPCDH WEMYDFWWCS GGFLGVPLTD AVPSQSLEKL VAQDFSRSPK VSQFLLFLIK
DQKSLRTHDI ISDAIFLPSE QLLPVLQTQL LRVALLLGLD VERGGRGAFP AEPTHAAAPV
GQRPDHPWRH PAHLAHPAGP DQRAAEERRP ERQPRQPSSH PGGGRRGGAT DAASVPRGAL
WPEAHRELSL EPSFEPLFGS VLLYDIKSKR RISETFHFDF NSEELKRMIG AKPELEGDAT
KCRQGIFSLS DPAADVFVVV KIDKVLQGCE INEASDPYLK EDKEKNREKL TLAAKDYCDR
LGAYRMPLGW MFIDLSSVLS GLSGASTSSE DVQASTITLN VDAESIVSAD RASCSTTGTF
RRVGSGTSSG GGRRTPLQKR RLFAGNSSQP NTPGLDAGSE QFIYSTASSD GKSPAPVGLN
ALCPVTLNFD SFFRHESDRL GDDDILKVLT DVRKQGSKFN RLKTFPAKWK LELSTVTDDL
LMKYSPELLK VNPFVPGPAH NAAKEVAEFP HDKLYAVNAS YRNLLYVYPK VANFSNRAGA
ARNICVKVEL MDSQESPLEC FFGKSSGPNF STKALTVVNY HNKCPQFSDE LKVRIPVDLN
DGHHLLFTFY HVTCRPSKPG EEVETPIGYS WIPLYRDGRL QTGDFHLPIS LDRLPQSYGY
LPPDVNLPNI KWLDGHKPLF SVSLRALSTV HTQDTHLDQF LKAFHSLSSA NKKLKRVTEP
ELKAAIQSVA KARPQPMVSF LYVIMDKLLA LIVSTPFSES ISSVCFEMIG QLVKICTLLL
DSFSDSHGRS SLLSTYIHYH KISLKDPVGF SVSPTTGSQP NGAPPKASFD PEELQSPAEN
SDLFEIIRDF ERSASTAKAS TFDSIDGGCK SHKLMHEELV RLWITSVGAA REMAFINSWF
FLELILKSMA EYLSVSNRMF LPRKLRFRDS FIADLSKLSH MIVQEIIEPS GKGKGSAAQI
NLSYAFFLRD CFSLADRSYV MALVKLYNKD LSAKIRWVEN TSSLAEPLST SLMLLKMDFM
RVVCSHEHFV MLNLPFGLGP SLSHSFSTAS YGSSSTGTAM SLSQTGNYPP SAPNLQPPSP
GGSSLSSRSA ESQCSGSVDL TPDFRAKHFL IGIVLSDLAA VLETTSQPLH ARAIGLVRNL
LATHEADSRL ADTVVKNRVA SLYLPLVGII LESSTQLYDP YSRSAKENAW SPSIINGNDS
VFSARGTTSS GPGINPKVAL AIAGMGGSGS PPTTPDEKTL KVETVKPNKP QLSLALSRQL
LACFCWTLKH LDRTTLRHWT RELSPGRMVQ LLDVLQLAVS CFEYRSPATI LESGDQARGE
LRQRLEDAIL GENSMAKEFL RKKSAGLAEN DGVRWRKDTK VTWKGAQYNS GGDVSDEGTS
GGDIDSVFEA TLCTEVSLTV LDTLELVIRV LNSPGSDHLS FALPIVLKIF MHMLACNQSV
TTLDNVFASQ RAVXXXXVLG ILFQMHMLAC NQSVTTLDNV FASQRAVVVK YPELIFEQQS
EQCGELCLQL LRHCASKLPQ IRSQAAASLY LLMRQSFECG SNLAKVKMQI TMSLSTLVSN
GTKLGFWLNE DHLRRSLKTV LTYSETDAHT DVQLKETTFS EQVKDLVFNL HMILSDTVKM
KDFSNDFEML LDLMYRVAKG YQNNPDLRLT WLLNMAGKHS DKGNYAEAGQ CVLHAAALAA
EYLSMTDYRE HLPRGAVAFE GISENVIQES ATSDDVISPD EEGICESAHF SEVGLVNLIE
KTAVFFEKAQ MYEQLLDIYK VLLNLRSKLP VPQILSPVLE EWRDYQRLAQ LHNRISVSLS
KIEPTVPMQD DLSDAWVSPL PTADKRCFGT YFRVAFYGSL FGDLDGVEFV YKEPAITKLP
EISHRLDGFY SDRFGKGTVE VIKDSNTVDR SKLNPSKGYL QITYVEPYLE GWERRRRPTY
YERNHKLHRF VYATPFTKDG KAHGELHEQY KRRTVLTTQH SFPYVKTRLR VCKREQTVLS
PIEVAIEDVQ KKTRELAAAT AQNPPDAKML QMVLQGCIGT TVNQGPIQVA NVFLADIVLD
EHGKPVDKLQ NKLRLCFKDF SKKCHDALIK NEQLIHFDQA DYQKEMKKNY MEFTKLMAPI
VSLSKFQTAN RCGQGDGIDR TVTDLVTRAV ELGPVTAV
//
