ID   A0A1I8ALQ1_9BILA        Unreviewed;       895 AA.
AC   A0A1I8ALQ1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Guanylate cyclase {ECO:0000313|WBParaSite:L893_g7075.t2};
OS   Steinernema glaseri.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC   Steinernema.
OX   NCBI_TaxID=37863 {ECO:0000313|Proteomes:UP000095287, ECO:0000313|WBParaSite:L893_g7075.t2};
RN   [1] {ECO:0000313|WBParaSite:L893_g7075.t2}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   WBParaSite; L893_g7075.t2; L893_g7075.t2; L893_g7075.
DR   Proteomes; UP000095287; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR   CDD; cd06373; PBP1_NPR-like; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR001170; ANPR/GUC.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   PANTHER; PTHR44755:SF11; ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1; 1.
DR   PANTHER; PTHR44755; NATRIURETIC PEPTIDE RECEPTOR 3-RELATED; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00255; NATPEPTIDER.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..895
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5009314852"
FT   TRANSMEM        473..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          682..895
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          525..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..667
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          856..895
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        545..569
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        584..612
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        869..883
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   895 AA;  102020 MW;  D274BF0C33E2BEF0 CRC64;
     MTTFVVLSLF VLLISVPGLG STAAFHYAAQ FPLDIVVGLP YDEGTRLRNP FRLTIGKAQP
     VFDVAVEDIY RRRKLLPHRA LRITYVDTQL SDAVGPQRIV DRYCAQSVDA VMGMAYVFAL
     APVARMSQYW QRGVPVFTTS AMVDELGDRV NFPLLTRLMG TYRTIAHLMI KTVSQFQWRR
     FHFFFNDQAV HGTSQGRSEC FFSLNAIKNV FNNQKDIVWS VEMFSEQVTR REQFEKLLKK
     ASLLTNIIIL CASPDTVREI MLAAYELGMA RSGEYVFINI DVSTGSHAEK PWIRANDTNS
     PENEKAKEAY RALKTISLRR SDRSEYKNFE ARVKDRAETK YNYSAKTGKE YEMNNFISAF
     YDAVLLYAIA LNETLTEGLD PRNGHNITSK MWNRTFVGIT GNVSIDQNGD RYSDYSLLDL
     DPDQDKFVEV AYYSGASNEL KQVAEFHWVN GKPPPDSPIC GWDHSKCPDG LPWYFYVIGG
     AAGVILVMSL VFCWYYHRMK LERELTAMSW KIRWEELDGD DSREKKKKAK RARKIDGYGH
     PDQSDPLLRS NSRSSFASDK RSSSSGATRK ISAMIDRKLS LFTRKKSSPT NEKNNTLEQN
     NHQANNQVPT ITEEMILRMD SPSDHCHGSL QASPLAENDV ERALVSSPSN SESNSKKKKS
     SNEEDYDIHA KRSLSSLKNR KLSFASIKSG GSVETIVQHN AQIYTPTAIY KGTMVAIKTL
     KIDPRRFPKI DLNRGHLMEL KRMKDLQHDH VTRFTGACLD APHYCIVTEY CPKGSLEDML
     ENEKIELDKM MKFSLLHDLV KGMHFIHSXX XXREDRTGQD DEVLAAPRLG QGDALHPQQR
     GAGPREVEVF QLRRRQQIRA EGHRLRPPQA PRHGGHRHRG DRRARLLQKE ALDRS
//