ID   A0A1I8API1_9BILA        Unreviewed;       366 AA.
AC   A0A1I8API1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Methylenetetrahydrofolate reductase [NAD(P)H] {ECO:0000313|WBParaSite:L893_g8115.t1};
OS   Steinernema glaseri.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC   Steinernema.
OX   NCBI_TaxID=37863 {ECO:0000313|Proteomes:UP000095287, ECO:0000313|WBParaSite:L893_g8115.t1};
RN   [1] {ECO:0000313|WBParaSite:L893_g8115.t1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00006743}.
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DR   AlphaFoldDB; A0A1I8API1; -.
DR   WBParaSite; L893_g8115.t1; L893_g8115.t1; L893_g8115.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000095287; Unplaced.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ   SEQUENCE   366 AA;  41943 MW;  298C48FEF50E0FB5 CRC64;
     MRTLEPIKHD DDAVRNYGTH LAIEMCRTIL TEGLAPSLHM YTMNREGSCR NILQAIGLWT
     QQPTRSLPWK PHGGHHPIRC KEDVRPIFWS ARPKSYIFRT KDWDQYPNGR WGNSSSPAFN
     DLQDYYLFYL KGTPTDVQMQ NMYGKELNSI EDVQKVFVNF ITQQENENGV KVTRLPWNEQ
     ESGTQPETTL IKEQLLWCNQ NGIFTINSQP AVNGAPSADP IVGWGKPGGY CYQKAYLEFF
     LEKGVAQKLK TVCAEYPRLS YHMINYNNTV EWTNGDSTTP IAVTWGVFPG CEVAQPTVVD
     PLSFRVWKDE AYDAWLTTWA AIYPEGSKST KVLREVHDNY YLVTVVDNDF VKDTVIFEAL
     EKAIAM
//