ID   A0A1I8ATU0_9BILA        Unreviewed;      1366 AA.
AC   A0A1I8ATU0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=PINc domain-containing protein {ECO:0000313|WBParaSite:L893_g915.t2};
OS   Steinernema glaseri.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Steinernematidae;
OC   Steinernema.
OX   NCBI_TaxID=37863 {ECO:0000313|Proteomes:UP000095287, ECO:0000313|WBParaSite:L893_g915.t2};
RN   [1] {ECO:0000313|WBParaSite:L893_g915.t2}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   WBParaSite; L893_g915.t2; L893_g915.t2; L893_g915.
DR   Proteomes; UP000095287; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   CDD; cd09885; PIN_Smg6-like; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR   InterPro; IPR019458; Est1-like_N.
DR   InterPro; IPR045153; Est1/Ebs1-like.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR   PANTHER; PTHR15696:SF40; TELOMERASE-BINDING PROTEIN EST1A; 1.
DR   Pfam; PF10374; EST1; 1.
DR   Pfam; PF10373; EST1_DNA_bind; 1.
DR   Pfam; PF13638; PIN_4; 1.
DR   SMART; SM00670; PINc; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          1184..1344
FT                   /note="PIN"
FT                   /evidence="ECO:0000259|SMART:SM00670"
FT   REGION          1..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1116..1141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..169
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..428
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..497
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..530
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1366 AA;  151963 MW;  13423C04B26BEE8F CRC64;
     MSEGSADAEA AKSRKRPEIQ IYRPGMMRKG TDITLTAKPT PAPPSRNQPP GEHRKKRQDG
     GPSRGGRSQK NENNASLSSL SEVRSLSGST TGFETASYRQ QKKNRRSGGG TPQSGQQSAS
     SSRQGSIADL SETQSLRNRG PRAAPPSGGG GGRRKQHHNS SQSLYDRPPT FNMARSEHYP
     VYPETQSLRR DQPRIRSQRG PNFTSNAHDY YNAPRAPPRL SDNLNPAGRP SGRRRLNSTR
     SIQSERPAAK NDSASNYGGH DFDETQSYCG EPFASCDDLL SQAGSVSSVA ASVLSIESIL
     KEHTASFDWT EELAKHEEEQ AKERKLQEEM ANESNEAAGP MSPRQRGIIS IKPAAMSSVA
     SEPHNKRNQK RRGRRNRNDS PSISSVSESI QENPSEDEGC RTPTYEQQES NGRRGIISNG
     TQLYSADRYS PIPSRAKPGA EADLMWRGGN AKVADRREQP RGRPTLNRGT SQSSEPSTPR
     PNQLDTVTFN IKSPQRQTQK HNDPKAKPPT PDNARVRSVK SPTSSATEQE IAQKYSADMK
     KYLEQIEGLC ENVSTGDVSS GKILNDVSAK LAKIYFDVFL LDINYTYVKK TDTFMWKQCF
     YGPIEALRTA SNTTKKCGKE FRNILIDFVD NSLKFYENLL HTIEEKVQFK IIDYLYWPNG
     VPSEDMLSCA VVNGGAKTSA NKDIKLALVL IHRQMISIGD LHRYKAMIRG NKDYSSCRLW
     YSKSAQLYPS NGRCYNQLAL IAMYAHRYLD TVFFYARAIS AKYAIETARH PLDAAFNEQH
     LRVDTYKNDV NERLGSGSTQ ITTTVERNDE IWILPDNGAK STRLSEVDSE KSDYFANEPV
     TSLYKWAIAY TLHAAGLIAT KIGMERYENV SERAVCLLRA LLDRAQCPLT ALQLVQIASI
     FIYCVHVNAL KKAPEDGTCS AQQQVAVQMI LTFWSLLMEP IIKNLDSLEG YLKGEPVDPK
     VSRVIPALST ISAWMSTPFV KDVYAGMPSL ESFHTPLVKV ETWQVFAKLA NELSRLVASG
     VMGLQSTSQS PRTGDAIEVV LPETIFMSSF CNVFPSEPQS VCLVKTNCSV LENADSSLLS
     LHARFSNILS AAEFLDGSEL RCFQFDSKSQ SFVCPGEFSE EEDDPVTPRK NSVVEPPVID
     HSSPTVVTEN QVISELERKK RENKLREQMR AADSTKPTLE VRPEYLVPDT NTFIDHLASL
     KKIIESKRFT TLVPTTVIAE LTGLSQPAAN LLANTKPGHM GATDIDHIDW VSEQARLAVQ
     YLRNVSESRT PGIYTITSNG NRQPSLNFVT EELPRSDDKK AVNDDRILSC CVQFEAKMSS
     STEPAEGTLK RRVVLLTEDR ALKIKAITMQ VPCRTIPNFV EWSRLT
//