ID A0A1I8B7E2_MELHA Unreviewed; 3584 AA.
AC A0A1I8B7E2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Transmembrane cell adhesion receptor mua-3 {ECO:0000313|WBParaSite:MhA1_Contig147.frz3.gene57};
OS Meloidogyne hapla (Root-knot nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC Meloidogyne.
OX NCBI_TaxID=6305 {ECO:0000313|Proteomes:UP000095281, ECO:0000313|WBParaSite:MhA1_Contig147.frz3.gene57};
RN [1] {ECO:0000313|WBParaSite:MhA1_Contig147.frz3.gene57}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR WBParaSite; MhA1_Contig147.frz3.gene57; MhA1_Contig147.frz3.gene57; MhA1_Contig147.frz3.gene57.
DR OMA; CVRNNAC; -.
DR Proteomes; UP000095281; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 7.
DR Gene3D; 2.10.25.10; Laminin; 28.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF28; FIBULIN-1; 1.
DR Pfam; PF07645; EGF_CA; 21.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 44.
DR SMART; SM00179; EGF_CA; 35.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00286; PTI; 10.
DR SMART; SM00200; SEA; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF82671; SEA domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 28.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 32.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50024; SEA; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..3584
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009315529"
FT TRANSMEM 3294..3319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 307..346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 550..588
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 650..688
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 749..788
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 799..840
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 852..891
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 964..1001
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1013..1051
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1063..1102
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1123..1302
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1514..1552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1564..1604
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1616..1656
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1721..1760
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1772..1810
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1822..1860
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1873..1911
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1979..2018
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2030..2069
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2078..2117
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2128..2167
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2178..2216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2228..2266
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2277..2315
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2381..2420
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2486..2525
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2537..2576
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2632..2671
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2747..2880
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 2929..3059
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 3056..3093
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3104..3143
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3152..3190
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3208..3246
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3253..3290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 184..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2362..2385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3488..3507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3555..3584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2369..2384
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3493..3507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3563..3584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1627..1644
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3280..3289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3584 AA; 395707 MW; 878D8110A6D23472 CRC64;
MQMLLLFATT LLSLTDILLA TKSDFCSSFG QFECNCGNPR CIDSNSVGDG VADCSDASDE
IRESSNIPCG DAKIPRKSAN NFKRNDDGTP RFCSKEKLRN CPEELGQICV EWPRNHQKCV
CRLGFFRAPG HAACLPVESF PHLNVSKVVD LSDEYASGRL NCSRLVSDLS MMYPGIFLFR
REGEAGGDEG EDKDERISTN NRRLNNKLPA RDEPPVSDDD ISDKEECTLI DGIDENKIGG
KGCSNGKICV VSGNKQNNNE IKGNATVKGI CARCIDNNFG YECLCPEGYL DTSLNPQQTP
GRSCRKLINE CLNPLQNDCS PNADCLDELV GFTCQCRLGF VDIGDEKRRG RKCVKNADTK
DNNKLCIGKN CEINLPPPEA ICDERAPEDA TYHCHCPAGF IVEYVDESQS VDFSKGKGKK
QHPRVAICLP IGSSEDEETT QQQQGYTNNS CLHCDLATSE CVGGVCRCLP GLIPLQSQQH
NFTNLKFSCV KSNGKYRGAN PCQDYSLNDC DSVAECDSDQ PGYFQCKCPS GYLDISPDKI
KMPGRICKKV ENECTSGKHK CDANAECIDT SDGYTCRCKP GWLDTSTDKE HSPGRSCKQS
SQCRNIDCAP EAECVENVLA GQPPICKCQR GYVDVSSKQG KLPGRICRLV RNECQHGEND
CSRDASCIDT DDSFTCQCKD GYSDESPQKD KKPGRICIRK NLPPTPECDV NDPMSCDKTR
HEACQFMSGT YRCACANGYS RLPDGRCLAI NECLDSRLND CSPDAECIDQ TIGFSCKCKN
DFVDVSPSGS RSGILCRRRV NECSAPKQYD VDCDSNANCI DTDESFICRC RPGFVDISEQ
FNRLPGRRCI EAVNECLDSK LNDCSEHAIC EDSKESYTCK CKSGFLDTSP DARKYPGRLC
IKPIQEKESN LTSNPFQLSL DTCDQTKGIN ACRKGLECIE DTDGNFICAC PEGSFLYSDG
TCRLTSACKL SMECDKNAIC VNLFDSFQCQ CRPGFFDKSP DPETKPGRIC KELVNECANQ
AHDCSPFAEC VDATDGFACI CKEGFVDISS QHELLPGRRC SNASNECADR SLNTCDESAD
CIDTQQGYSC RCIPGYVDVS TSANLPPGRV CTVQTSCPKQ KTDLMFLVDG SGSIGSAVFR
NEVLRFISDF VELFDIGQEN TRVGLIQYSD QIRHEFDLNQ YSDKHSLLQA IAQTQYLTGL
TRTGAAIQHM VQEGFAQRRG ARPPSSDVSR VAIVITDGRS QDNVTEPAQM ARGQHINTFS
IGVTDHVLAS ELESIAGSQQ RWFYVDRFKD LDMRLRSIVQ KLACPSPSRP TQLSTGCSVD
AQTGCDRTRN EICTLINKKP TCHCPNGGFD RHPLTHVCGG ELCNPELPTS CPHPELCQRT
PFGNHRCACP ASYAREMHSG ICISSSISRI SSGQHLPSNF TSTTFSPSLA VKTCPPGMAL
NPRSGNCGPP GSCDPLRKSE DECDIRKREH CLLHTSGQFH TCQCLPGEKR HPATEICYQS
PDPVNKPGRL CVGEVNECAL GQTRCSPDAL CVDTPEGYIC RCKPGFVDLS PNARHESGIV
CRKLVDECSR EELNTCHPDA FCVDTHDSYK CICKAGFSDL DEFRNPGRQC VKVQESNSKC
QEGRNDCDKN ARCIYDASTD KYECVCPPNF RDKSVDLVNA PGRVCIPFIP ECDNPALNDC
DLPDHAICTD TDEGYTCRCR QGFLDISPNV THKPGRLCKQ LENECAKGTH DCAKEGGICQ
DTPDSYTCQC SANYLDVSLD RKTRPGRNCK RLVNECAAGQ HDCFPTAICT DTEDSYQCQC
PKNYLDVSSD PLQKPGRRCL AKIDECTQGL HDCSPNAICN DTDSGYTCKC SQNFVDESPE
SAQRPGRICR PALVNECVLK KDDCHSDADC LDLAQGFTCQ CRSNYLDQSS NRVTHPGRYC
VPRPTPPPDE CQLTAVNKGC KAELNEVCRI VGGQPKCACP LNYERATTKN NTGTAACTVI
NECQFPQLND CHPSAECQDL VDGFTCKCRS GFKDISPKAN ERPGRLCQAL VNECQFPHLN
DCHLHAECID LEDSFQCRCK KGFNDLRPER PGRICKQMID ECERPELNSC DRNAKCLDEE
DGYNCECKSG FADVSPSPNL SGRACRPIVN ECVDQKLNDC DPRAKCIDQP DGYQCECPSN
TKDISPSAAF PGRVCHVFEN ECLTGKHDCD PQAVCQDNEQ AFTCECPKGF TDRSPNRQHR
PGRVCVKLVD ECKEGRHTCS PNADCRDLEE GYTCECRDGY VDRSTNLAIQ PGRVCGVPET
CPANHECSAA AVCEPQGGNN YTCTCIQGYI DQSPDGVSGR ICVRNSFCRD PKLNNCSRKA
VCYEEGQGYR CECARGYLDK SPSGQPKGRV CELPPPPPPP QRHPCQDSSH DCHQKAACRA
TGAAAFTCEC LPGYEDRSPD VKTKPGRVCV LTEPICIDAT RNDCHSAAVC TEDKRLPEGF
ACRCRDGYVD QSPDKIRKPG RICVEFVNEC LDRALNDCDP LAICEDQSEG YTCRCPLNAM
DRSPDKERRP GRKCISQINE CANPSLNNCS RFADCFDKPE GYECRCRPDY HDLNTAQPGT
SCKFMQNECL NLALNDCSLN ADCFDTPSGY NCKCRHPFKD HGPAEHPGRI CLYNECQDPT
RNKCDKNAIC EDTEDGFTCR CNDGFYDDSG TKGLEAGRVC IAFSENEQPE HITQRPSHQQ
QSTVIKGIAC GRNHWCLSER NEVCVGGTRC LCRPGDGRAS NEQKCVPVDR TSFAFRVISR
GSQPLFYSSD YGDSSSSTYV EFVQEFQREL ARAIGSTKFA PHYVTTDVSY LTHPKAINSS
WSDGLLVNFT IASNKNQQPL NRCELWEQLS SSIQHSNGAI GNNGQLIVAP DFELLNPCIK
QLPIGDYCGG SEDTAAICKK ELGEICIAET LCGCPNGQKR PSTEEKCRPV ESWPIPLWII
RRNNHNLAFN ETFANPLNPL NKEYVRLFEK GIAQCYPQTL LKNAFVSVEV NEILDPMLIN
SSWDNGLLFN ATMHFRKGAV KNPLDVYTQL VKYIIDKNGQ QLGSSGLYLS SNQKNPFSSC
FKNNCHPKGI CIELGPNAYR CECSNGQRDL NPSDPGRKCV PTQSYNECER EEENECSTEA
RCIDLEFLYK CECKKGYTDA SPKGSIPGSV CVLDYCSDVN YCPSNTSCVN TEQQAECQCH
KGFIDIRHSE SRMSLGFSSD QYCLSPRDVD ECALGLHNCS SYAICTNLPE GYQCQCPSGW
EDGNLELPGR FCASKLCAQC HENGACIPDP TNNTNVICQC FDGYSGQFCE LAPAAASLVL
LVLLALVFLL LSLCFLLYLC TRCRCFYRRP EFATLDASAS SDSGADFSLY GIPRAKLKQS
SHTDSAADSR AAQLAGYLED GIRIPRAHLH HDGSSLGSAA SSEFTIREEI ERRVTTDITR
TEEIVTDVDV HNEATALSSE NIAEASNAFP STLGTSTNLR KNQQYQRQQQ HKLIDNELDR
GESIAEFSNS RREGGGGISS SNRGITINHP SSSWRHYATT NDSLKKGFAF KNPALENDED
VDIIDKNTTV RHHRHFDPRT GISSDKHIQQ SSTISSTTRS GGKY
//
