ID A0A1I8B980_MELHA Unreviewed; 502 AA.
AC A0A1I8B980;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Geranylgeranyl transferase type-2 subunit alpha {ECO:0000256|RuleBase:RU367120};
DE EC=2.5.1.60 {ECO:0000256|RuleBase:RU367120};
DE AltName: Full=Geranylgeranyl transferase type II subunit alpha {ECO:0000256|RuleBase:RU367120};
OS Meloidogyne hapla (Root-knot nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC Meloidogyne.
OX NCBI_TaxID=6305 {ECO:0000313|Proteomes:UP000095281, ECO:0000313|WBParaSite:MhA1_Contig1606.frz3.gene5};
RN [1] {ECO:0000313|WBParaSite:MhA1_Contig1606.frz3.gene5}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- FUNCTION: Catalyzes the transfer of a geranyl-geranyl moiety from
CC geranyl-geranyl pyrophosphate to cysteines occuring in specific C-
CC terminal amino acid sequences. {ECO:0000256|RuleBase:RU367120}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] =
CC diphosphate + S-geranylgeranyl-L-cysteinyl-[protein];
CC Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533,
CC ChEBI:CHEBI:86021; EC=2.5.1.60;
CC Evidence={ECO:0000256|ARBA:ARBA00001577,
CC ECO:0000256|RuleBase:RU367120};
CC -!- SIMILARITY: Belongs to the protein prenyltransferase subunit alpha
CC family. {ECO:0000256|ARBA:ARBA00006734, ECO:0000256|RuleBase:RU367120}.
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DR AlphaFoldDB; A0A1I8B980; -.
DR WBParaSite; MhA1_Contig1606.frz3.gene5; MhA1_Contig1606.frz3.gene5; MhA1_Contig1606.frz3.gene5.
DR OMA; VIELAMN; -.
DR Proteomes; UP000095281; Unplaced.
DR GO; GO:0004663; F:Rab geranylgeranyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0097354; P:prenylation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.120; Protein prenylyltransferase; 2.
DR InterPro; IPR002088; Prenyl_trans_a.
DR PANTHER; PTHR11129:SF2; GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11129; PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT; 1.
DR Pfam; PF01239; PPTA; 3.
DR SUPFAM; SSF48439; Protein prenylyltransferase; 1.
DR PROSITE; PS51147; PFTA; 3.
PE 3: Inferred from homology;
KW Prenyltransferase {ECO:0000256|ARBA:ARBA00022602,
KW ECO:0000256|RuleBase:RU367120}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|RuleBase:RU367120}.
SQ SEQUENCE 502 AA; 58225 MW; F5954B050F479DA5 CRC64;
MMHFVKKSQV SEGEKTAYEK KRAAKLERFV QMKERIFEKR KIGEYDEEIM ELTAELLGKH
ADIYTFWNIR REAIERICVK LEGESEKENI ERKSKLLDKE LKLTQECLMK NPKSYSSWHH
RFLVVSQRPK INFQEELALC DNALALDCRN FHCWGKFFSD RLIGKNPSNY SAWHYRGTLL
PRLEENRKEI SEGRLLTDEC LKGEFEKVLH VCGVNSEDQT AWTYCRWLVE LATNGLPNSP
QIVAARFLDS TTVLVVFSEA VNKQVVKNSF NLFDYSKIMK FESFSPFKTS DFVSEFKYSH
VWLLSNVSSP LLICPLNQEG KDEAEIKQIE IDKIFVDGFY FQKNFTSSAI NVRELPRKCL
DDLIKLCNDL IPVEDNPWAL AALTRAMFYL KGINKQTFEL AKDNCEKLKK IDFQRSEMYE
ELMDKYRLIK SLNEESSPAG GTLLSKLIEG NRQLNLKEIG LKSLDNIPLL SAFVSTDNLI
NDNLMALKNL TLDGNPTKEE SK
//
