ID A0A1I8BE90_MELHA Unreviewed; 368 AA.
AC A0A1I8BE90;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Cathepsin F {ECO:0000313|WBParaSite:MhA1_Contig1986.frz3.gene9};
OS Meloidogyne hapla (Root-knot nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC Meloidogyne.
OX NCBI_TaxID=6305 {ECO:0000313|Proteomes:UP000095281, ECO:0000313|WBParaSite:MhA1_Contig1986.frz3.gene9};
RN [1] {ECO:0000313|WBParaSite:MhA1_Contig1986.frz3.gene9}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR AlphaFoldDB; A0A1I8BE90; -.
DR WBParaSite; MhA1_Contig1986.frz3.gene9; MhA1_Contig1986.frz3.gene9; MhA1_Contig1986.frz3.gene9.
DR OMA; RSATPFW; -.
DR Proteomes; UP000095281; Unplaced.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF959; CATHEPSIN F; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 71..128
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 155..367
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 368 AA; 42124 MW; E29FF6975AEC0DB6 CRC64;
MQTLNSRFSS SFSIFPIKLT LVVGLYVEKD AVFRYSDSEP IEFLSMPIKP ISELSKRSGN
YIRGWHSARE WHSIFQRFGP NYSKASEVLN RFNNYLKNLV RAKKYQKKEL GTAIYGETQF
MDLSKDEFRK IYLPFQWPLN IENIQIAPNI EDEDLPSSWD WRTKGAVTEV KNQGQCGSCW
AFSVTGNIEG QWALKKGKLQ ALSEQELLDC DRVDMACNGG LPLQAYKEII RIGGIEPEKD
YPYDAKKEHC NLNRSDLVAY INGSLQLKKD EIQMAKWLVK NGPISVGVNA FPLQFYRHGI
SHPLRFLCAP QMLNHGVLIV GFGQEGNKPF WIIKNSWGKT WGEHGYYRLY RGSNVCGIHE
MATSAVVN
//
