ID   A0A1I8BJ42_MELHA        Unreviewed;      1673 AA.
AC   A0A1I8BJ42;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE            EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
OS   Meloidogyne hapla (Root-knot nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC   Meloidogyne.
OX   NCBI_TaxID=6305 {ECO:0000313|Proteomes:UP000095281, ECO:0000313|WBParaSite:MhA1_Contig2496.frz3.fgene1};
RN   [1] {ECO:0000313|WBParaSite:MhA1_Contig2496.frz3.fgene1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|RuleBase:RU363044};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU363044};
CC   -!- SIMILARITY: Belongs to the helicase family.
CC       {ECO:0000256|RuleBase:RU363044}.
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DR   WBParaSite; MhA1_Contig2496.frz3.fgene1; MhA1_Contig2496.frz3.fgene1; MhA1_Contig2496.frz3.fgene1.
DR   Proteomes; UP000095281; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR   CDD; cd18809; SF1_C_RecD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR010285; DNA_helicase_pif1-like.
DR   InterPro; IPR025476; Helitron_helicase-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR049163; Pif1-like_2B_dom.
DR   PANTHER; PTHR45786; DNA BINDING PROTEIN-LIKE; 1.
DR   PANTHER; PTHR45786:SF79; HOOK MOTIF PROTEIN, PUTATIVE-RELATED; 1.
DR   Pfam; PF14214; Helitron_like_N; 1.
DR   Pfam; PF05970; PIF1; 1.
DR   Pfam; PF21530; Pif1_2B_dom; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU363044};
KW   DNA damage {ECO:0000256|RuleBase:RU363044};
KW   DNA recombination {ECO:0000256|RuleBase:RU363044};
KW   DNA repair {ECO:0000256|RuleBase:RU363044};
KW   Helicase {ECO:0000256|RuleBase:RU363044};
KW   Hydrolase {ECO:0000256|RuleBase:RU363044};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU363044}.
FT   DOMAIN          578..767
FT                   /note="Helitron helicase-like"
FT                   /evidence="ECO:0000259|Pfam:PF14214"
FT   DOMAIN          1510..1554
FT                   /note="DNA helicase Pif1-like 2B"
FT                   /evidence="ECO:0000259|Pfam:PF21530"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          130..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          542..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1673 AA;  189456 MW;  28DCB9284920B382 CRC64;
     MPSKQHLARK KRKERYQSTG TPKSLLQDCG PPAQIAVETC NDNVPNFDRA RSPTLVPPFS
     VSGSSTSVHP FSVSQLGLGV SSLGVAPSTS SVGPFSSSRA LIRSDSLSSE TIDKIPRFDD
     TTSICSSIDT DSDISSVCSS RGRGRPKKKV RSSGRPKKTS MSINNNESIV VEHIIPDEGI
     VVNEEPFTFL EPDPPSRNVR RSERIMNRQS TATPSQIFPN IPDSPKIDKV NPIESYCTRR
     HKGFPCADVR AKHTTEYYDS GDIGSSVCHY CDALLFESEV NLQHKTKFKT ISSSFCCGCG
     AVSLPPYSTH PKDLQELLKG ETKDSKEFLA YQNSYNSLLA FASVTVGHKD SSLDGSVCFM
     LNGEFSRHLS SMHSGNLTPS FSQLYILDAN EALNLRTQNS ICGGDRVNPE TLKKLDALLR
     TLHPFAKVYK NFHSQYQAIL EKDGPDSVKK FRLTLLEERD APAPVKDKSL HTRQVNLPQE
     KSLFSVWTES DEPPQLKGIY ITDLQGSLFQ LPAYHPMTDT LCYPLLFPNG DDGFHKNVPF
     VRITKPPTND DENSSNERSD DELEIDPSRK NFTTLRDYIR YRLAIRQSDS PHNIWSAGGG
     LSQKIVLDYA ARIDAEVASF LRKPEFNLRA TLPENVLKHL AKDANLESVD QLGSVIFFHK
     NNPGTRPYFQ DMFYDATTIM SRTRKEGCAS FMFTFTTNPR WPEIKRNFIR KDQKLVNRFD
     ILCRIYADKL RKLHFLLDKK NIFGNILGYA ESMEFQKRIG GPHLHRVFCT DTEATAENID
     NLIWAHIPPK PDDSDQSAWA NFIRKVRELL PKFQIHDCGD HCKGSNGRCM KGFPKPFSRQ
     TILHDNKPAD YYRPSPTDGG ETLQVKHGST YITYDNSRIV PYNPFILVMF QSHHNLEYAY
     GQSDNLKYAL KYPFKGASFS YIKCQDNTVN VDEPAQYARM LFRSPAEAFC RIMSYKYAYL
     SHTVIPLTIH LPGQQKIYFA PATRKNNLKR VQKGILPETP LTQYWKMWKN GVIDKTILFE
     NMPEKYSWKS DEKIWKERKF STRDDKIKLR KLTIGRIYTI SPREPEKFAL YVLMKHFPGD
     PDHLKNVNGK FCDTFADAAR LRGLFEDNSV WERTLREASY SLPPSQIRQL FVNILVFGST
     ESCIIDAPRL WEMFMESMYD RRCPDAEKPR RVDKALAIIE RYLLANGKQM KDYGLPLPKN
     SLSNDPNKAI DEFFFPQHVN DDDIDGTVDT SSFEKAKLNT EQDKFFKLVR DSVMDPNPKD
     RKKVLATAST GIASTKFYAG GMTLHSAFRF GINHESGQIP SVPFDSYFGR RIIESNLIII
     DEITMLEKTM IENVDLLCRT MVPQNKDLPF AGKVVIISGD WKQSLPVVIN SSSHEAQVAV
     CLQSSHLYNI FHKTRLIQNM RLRPSELQFK DWLYKLGTDT SGDKIAIPKS MIVETRDELI
     AFVFDKGFDI PSSDLLKRLM LAPTNKSVDL NNSIVLTSLQ SQSMDYFSID KCLTEDPLSP
     YAADFDIAQL NNLTPTGMPA HHLHLKVGSI LVLLVNLNTS KSLCNGTRLI VRKLHTNLIE
     AETISGSNHG MTIGISRVRS TYKDKRPDGV SFERFQFPVR IAFAMTITKV QGQTCERLGI
     DLSDDPFAHG QLYTALSRAT NSDLIRVYAP GKPRDSEGNI LITNVVARGL RFD
//