ID A0A1I8BRX8_MELHA Unreviewed; 634 AA.
AC A0A1I8BRX8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
OS Meloidogyne hapla (Root-knot nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC Meloidogyne.
OX NCBI_TaxID=6305 {ECO:0000313|Proteomes:UP000095281, ECO:0000313|WBParaSite:MhA1_Contig53.frz3.gene21};
RN [1] {ECO:0000313|WBParaSite:MhA1_Contig53.frz3.gene21}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR AlphaFoldDB; A0A1I8BRX8; -.
DR WBParaSite; MhA1_Contig53.frz3.gene21; MhA1_Contig53.frz3.gene21; MhA1_Contig53.frz3.gene21.
DR OMA; MSAKFNN; -.
DR Proteomes; UP000095281; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09919; SH2_STAT_family; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF43; SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|RuleBase:RU046415};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 27..175
FT /note="STAT transcription factor all-alpha"
FT /evidence="ECO:0000259|Pfam:PF01017"
FT DOMAIN 197..314
FT /note="STAT transcription factor DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF02864"
FT DOMAIN 312..374
FT /note="Signal transducer and activator of transcription
FT linker"
FT /evidence="ECO:0000259|Pfam:PF21354"
FT DOMAIN 393..435
FT /note="SH2"
FT /evidence="ECO:0000259|Pfam:PF00017"
FT REGION 528..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 634 AA; 71792 MW; C2130C82C4EB3C04 CRC64;
MQSSSTSSIS PSNNEQQRMA LSLVAKDCQL LWEENKDMQG RFVNDISELQ NFQAVIERLE
HEQRHDQLGR AKQTLLVKGK KVKRLNDGVH LIAVMQNNLI SVRLMEWKNA QKLAQIGMGF
DQREMQLDEI QSEFEVLAEN NWTLRAYACW QIDLLRRPTL LADSSAPTHI TNLSQILETL
TKMLCMLVSQ SFVVAVQPDP VLKTQHKFVA EVRLLIGDRL GIKQQLVNTN VTVKIIAEDE
AKMLGTGQIN EKDIKMVGSI SNDLEKLILD ERGHMSAKFN NSKLTRIAHR KPPAKGSLST
SQIAQTATDQ NQVLRHKFTL FTGAHRPLSD SDLAYLGDKL GIVHSNPDNK PITFQRFAKQ
NLREDVNFSF WEWFFLIMQL IKQKLLKFWD DGWLVGFISK HEASERMLMC HNPTFLLRFS
DTQTGAVSIG FVCEEDGAKG KKNTFLYYNV PFHLAPFTIK DLDQLSLASR IQSCPQLKEV
PYLYPDIDKE QMLAHFDTEE RCKIFESPAG YIGSEIVMVA KTMSNSKLGS AVGSDSPSPM
SNQWSPSEFQ QSVSMDVGDD IVAMLGQNHQ LDSANVESLL GLPPQQQSRM SSEQPLQQLD
LSFMDVFHQQ QQQHINRNYL GGGNSMLSQP PNSH
//
