ID   A0A1I8BYY3_MELHA        Unreviewed;       615 AA.
AC   A0A1I8BYY3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Transketolase {ECO:0000256|ARBA:ARBA00016662};
DE            EC=2.2.1.1 {ECO:0000256|ARBA:ARBA00013152};
OS   Meloidogyne hapla (Root-knot nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC   Meloidogyne.
OX   NCBI_TaxID=6305 {ECO:0000313|Proteomes:UP000095281, ECO:0000313|WBParaSite:MhA1_Contig812.frz3.gene5};
RN   [1] {ECO:0000313|WBParaSite:MhA1_Contig812.frz3.gene5}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000256|ARBA:ARBA00001941};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the transketolase family.
CC       {ECO:0000256|ARBA:ARBA00007131}.
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DR   AlphaFoldDB; A0A1I8BYY3; -.
DR   WBParaSite; MhA1_Contig812.frz3.gene5; MhA1_Contig812.frz3.gene5; MhA1_Contig812.frz3.gene5.
DR   OMA; HKVYCLC; -.
DR   Proteomes; UP000095281; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR   CDD; cd02012; TPP_TK; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR020826; Transketolase_BS.
DR   InterPro; IPR033248; Transketolase_C.
DR   InterPro; IPR049557; Transketolase_CS.
DR   InterPro; IPR005474; Transketolase_N.
DR   PANTHER; PTHR43195:SF1; FI06132P-RELATED; 1.
DR   PANTHER; PTHR43195; TRANSKETOLASE; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR   PROSITE; PS00801; TRANSKETOLASE_1; 1.
DR   PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          311..475
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   615 AA;  66782 MW;  E8F0519E06E44C82 CRC64;
     MEDQISKLSD AANRMRISSI EQTAKANSGH PTSSCSAAEI VATLFFSEMR YSVKEPRHPS
     ADRFVLSKGH ACPILYAAWE EAGLLTREQV LTLRKLDSDI EGHPTPRLEF IDVATGSLGQ
     GLSCAAGMAY TGKYVDNASY RVYCLLGDSE SAEGSVWEAA AFASYYKLDN LVAIVDVNRL
     GQSRETMLGH DLFTYAKRFE AFGFHSIIAD GHDIADLLKA FDEAKKVTGQ PTAIICRTLK
     GKGIEGVEDK DNCHGKPVAL DKAEIIASKL TNKTKIPWEL ENLINDAPNV DFEIGNIKMS
     SPPNYQIGEK VATRLAYGNA LVKLADTNKR IIALDGDVSN STFSDKVLNK YPQQFVQCFI
     AEQNMVGVAV GMSCRGRTIP HASTFAVFFT RAADQIRMGA ISFANVKFAG SHAGVSIGED
     GPSQMGLEDL ALFRAVPNSI VLYPTDAVSA EYATELAANY KGITFTRTGR PNTPVIYPND
     EKFEIGKCKV IRQTNEDKYL LIGAGVTLYE CIKAHDMLSS EGIQVAVIDL FSVKPLDSQT
     LIEQAKRVGG KVLTVEDHYQ TGGIGEAVAL ALGDVPGVRV RSLCVKEIPR SGTPDELMDL
     YGISAKKIIA AVKNY
//