ID   A0A1I8C238_MELHA        Unreviewed;       204 AA.
AC   A0A1I8C238;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 {ECO:0000256|ARBA:ARBA00040793};
DE            EC=3.1.7.2 {ECO:0000256|ARBA:ARBA00024387};
DE   AltName: Full=Metazoan SpoT homolog 1 {ECO:0000256|ARBA:ARBA00041464};
DE   AltName: Full=Penta-phosphate guanosine-3'-pyrophosphohydrolase {ECO:0000256|ARBA:ARBA00041770};
OS   Meloidogyne hapla (Root-knot nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC   Meloidogyne.
OX   NCBI_TaxID=6305 {ECO:0000313|Proteomes:UP000095281, ECO:0000313|WBParaSite:MhA1_Contig953.frz3.gene3};
RN   [1] {ECO:0000313|WBParaSite:MhA1_Contig953.frz3.gene3}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: ppGpp hydrolyzing enzyme involved in starvation response.
CC       {ECO:0000256|ARBA:ARBA00037781}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP +
CC         H(+); Xref=Rhea:RHEA:14253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:58189, ChEBI:CHEBI:77828; EC=3.1.7.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00024273};
CC   -!- SIMILARITY: Belongs to the MESH1 family.
CC       {ECO:0000256|ARBA:ARBA00038354}.
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DR   AlphaFoldDB; A0A1I8C238; -.
DR   WBParaSite; MhA1_Contig953.frz3.gene3; MhA1_Contig953.frz3.gene3; MhA1_Contig953.frz3.gene3.
DR   OMA; PPWRERK; -.
DR   Proteomes; UP000095281; Unplaced.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   PANTHER; PTHR46246; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR   PANTHER; PTHR46246:SF1; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
FT   DOMAIN          57..152
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
SQ   SEQUENCE   204 AA;  23250 MW;  73CADD35F16870EB CRC64;
     MNGMDKNSSF EKSKLYPELN EDIQIKNNED MSIVIKAADF ASRRHRFQSR KDGRTPYINH
     PIGVAYLLTS VGNITDPATL AAAYLHDTIE DTKTTFEELE QEFGSEIAEI VRECTDNAKL
     SKAERKNEQV EKAAKCSHKA KLVKLADKLY NLRDLERHIP PAFGKQGARE YFSWAKKVVF
     QLKGTNEALE VALDDVINRF LEKQ
//