ID   A0A1I8C412_9BILA        Unreviewed;       452 AA.
AC   A0A1I8C412;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Lysosomal acid phosphatase {ECO:0000313|WBParaSite:RSKR_0000003300.1};
OS   Rhabditophanes sp. KR3021.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Alloionematidae;
OC   Rhabditophanes.
OX   NCBI_TaxID=114890 {ECO:0000313|Proteomes:UP000095286, ECO:0000313|WBParaSite:RSKR_0000003300.1};
RN   [1] {ECO:0000313|WBParaSite:RSKR_0000003300.1}
RP   IDENTIFICATION.
RC   STRAIN=KR3021 {ECO:0000313|WBParaSite:RSKR_0000003300.1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC         Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000032};
CC   -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC       {ECO:0000256|ARBA:ARBA00005375}.
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DR   AlphaFoldDB; A0A1I8C412; -.
DR   WBParaSite; RSKR_0000003300.1; RSKR_0000003300.1; RSKR_0000003300.
DR   Proteomes; UP000095286; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd07061; HP_HAP_like; 1.
DR   Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR   InterPro; IPR033379; Acid_Pase_AS.
DR   InterPro; IPR000560; His_Pase_clade-2.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   PANTHER; PTHR11567:SF110; ACID PHOSPHATASE 1, ISOFORM B; 1.
DR   PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR   Pfam; PF00328; His_Phos_2; 1.
DR   SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR   PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..452
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5009316505"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          429..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   452 AA;  51877 MW;  07479D91381110FA CRC64;
     MLKRSLVLFL VIAAAWRGES GNTFDTGRLV DVKADLSTLE FVTTIFRHGD RTPVALMPTD
     KANDEESWII GLGELTKEGM AQQYRLGQWI RKRYDSFIST EYSSYEIYAR SSDYNRTLMS
     GQANLAGLFK PTNHTTQFLP GLLWNPIPVH TLPKEDDRQL YDEVECPILH HEIDRVYSED
     PQVLQLEKEN ADFLSFLGNN SGLAKDTLRL KDMWLVFDSL NAEYCHQDEH QIPGWVNSTV
     WSKIQSLYDQ SSRFLHSNDL LKKLKSGPLL QEISRRLRLK AANQLDSRHK YYMYSAHDTS
     VSAILAAFGI IPETFPNYAT MAMIELHRSQ DDHIIKIFYK NVTDGENVYE YDIERCPSPC
     SLTSFMASTE IYIPKAWKVD CGIVKWYEWD PSTYFALIAM LAFCAFFFAS LIGIECGLRY
     FNKKQATTAN RNDSREEGDD TAPLINDSSE EV
//