ID   A0A1I8C5K2_9BILA        Unreviewed;      1584 AA.
AC   A0A1I8C5K2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=CULLIN_2 domain-containing protein {ECO:0000313|WBParaSite:RSKR_0000088300.1};
OS   Rhabditophanes sp. KR3021.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Alloionematidae;
OC   Rhabditophanes.
OX   NCBI_TaxID=114890 {ECO:0000313|Proteomes:UP000095286, ECO:0000313|WBParaSite:RSKR_0000088300.1};
RN   [1] {ECO:0000313|WBParaSite:RSKR_0000088300.1}
RP   IDENTIFICATION.
RC   STRAIN=KR3021 {ECO:0000313|WBParaSite:RSKR_0000088300.1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   WBParaSite; RSKR_0000088300.1; RSKR_0000088300.1; RSKR_0000088300.
DR   Proteomes; UP000095286; Unplaced.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 7.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF169; CULLIN-1; 1.
DR   Pfam; PF00888; Cullin; 4.
DR   Pfam; PF10557; Cullin_Nedd8; 2.
DR   SMART; SM00182; CULLIN; 2.
DR   SMART; SM00884; Cullin_Nedd8; 2.
DR   SUPFAM; SSF75632; Cullin homology domain; 2.
DR   SUPFAM; SSF74788; Cullin repeat-like; 3.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 2.
PE   3: Inferred from homology;
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          881..1110
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   DOMAIN          1212..1450
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   1584 AA;  182168 MW;  58A1993DC94E4B65 CRC64;
     MLVTEYKIQL FNKFSPSLVT AVLQLIEKER NNQSINSGLI SETLQSYVYM GVTLDTGAIP
     KSMPIKDSTA PTFQKKDDSE KVVIHSVKNT AIYKQQFEIE FVGQTKAWYE RHSAQLLEVA
     DVPEYLMKAE GWMTAEIDRC DRLMDKSTLD PLQLCLNQSL ITDHLDIFRA QFEGLLANDK
     QDDLRRLYTL SFGTPDAELH FTTILKKYIS TYGVEKINGI ADDAKDDPKM YLTSIIEIYN
     QFTSVVQTSF KNDKAYVEAL DKAFQEIINA NRVVANDRRG KKTHELVAKY ADTILKKTNR
     IADYSNQLTA KFNGLYGDDL LREYNQIWIN FLLSSSVTNG IFRYLNRHWI TRKLEEGSDN
     VRFIINMLVT EFKNQLFDKF SPSLVTAVLQ LIEKERNNQS INSGLISETL QSYVYMGITL
     YTGVIPTSMP TKDNTAPTFK KKDDSEKVVI RSVKNTAIYK QEFEIEFLGQ TKAWYERHSA
     QLLEIADVPE YLMKAEDWMT AEIDRCDRLM DKSTLDPLQL CLNQSLITDH LDIFRAQFEG
     LLANDKKDDL RRLYTLSLGT PDAELHFTTN LKKYISTYGV EKINGIADDA KDDPKMYLTS
     IIEIYNQFTS VVKTSFKNDK AYVEALDKAF QEIINANRVV ANDRRGKKTH ELVAKYADTI
     LKKTNRIGDS CELDEKLKDI VTVFSVKNTA IYKQEFEIEF LGQTKAWYER HSAQLLEIAD
     VPEYLMKAED WMTAEIDRCD RLMDKSTLDP LQLCLNQSLI TDHLDIFRAQ FEGLLANDKQ
     DDLRRLYTLS FGTPDAELHF TTILKKYIST YGVEKINGIA DDAKDDPKMY LTSIIEIYNQ
     FTSVVKTSFK NDKAYVEALD KAFQEIINAN RVVANDRRGK KTHELVAKYA DTILKKTNRI
     GDSCELDEKL KDIVTVFRYI EDKDSFLQFY SRSYARRLIN DLSVGDDSEM SLINSMKAIC
     GFDYTTKLMK MNKDMALSKS VSDEFKQSRL QQPAQPKKVD FSIHILTNGS WPYKQVYTLQ
     VPKCMKSTME DFSSFYIQKH SGRKLTFLFD QSKGEIQCNA FAKKHIFVCL TNQMAIIMQF
     NDKDSCTYGE LKRALQSGDT ELKAALLGFA KNDILLVDGA TFKVNEGKEV TEETVYLLNT
     NFTNKKVKID LTKGTAKVET NKGLQTMNAS IESDRKLHLE AIIVRIMKAR KEMRHQQLVS
     DVVGFVKKRF RPEIPHIKRS IDVLIEKGYI KRDANERDLI GDSCELDEKL KDIVTVFRYI
     EDKDSFLQFY SRFYARRLIN DLSVGDDSEM SLINSMKAIC GFDYTTKLMK MNKDMALSKS
     VSDEFKQSRL QQSAQPKKVD FSIHILTNGS WPYKQVYTLQ VPKCMKSTME DFSSFYIQKH
     SGRKLTFLFD QSKGEIQCNV FAKKHIFVCL TNQMAVIMQF NDKDSCTYGE LKRALQSGDT
     ELKAALLGFA KSDILLVDGA TFKVNEGKEV TEETVYLLNT NFTNKKVKID LTKGTAKVET
     NKGLQTMNAS IESDRKLHLE AIIVRIMKAR KEMRHQQLVS DVVGFVKKRF RPEIPHIKRS
     IDVLIEKGYI KRDANERDLY QYLA
//