ID   A0A1I8CAW7_9BILA        Unreviewed;       930 AA.
AC   A0A1I8CAW7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   22-FEB-2023, entry version 29.
DE   SubName: Full=Toprim domain-containing protein {ECO:0000313|WBParaSite:RSKR_0000258100.1};
OS   Rhabditophanes sp. KR3021.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Alloionematidae;
OC   Rhabditophanes.
OX   NCBI_TaxID=114890 {ECO:0000313|Proteomes:UP000095286, ECO:0000313|WBParaSite:RSKR_0000258100.1};
RN   [1] {ECO:0000313|WBParaSite:RSKR_0000258100.1}
RP   IDENTIFICATION.
RC   STRAIN=KR3021 {ECO:0000313|WBParaSite:RSKR_0000258100.1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the type II topoisomerase family.
CC       {ECO:0000256|ARBA:ARBA00011080}.
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DR   AlphaFoldDB; A0A1I8CAW7; -.
DR   WBParaSite; RSKR_0000258100.1; RSKR_0000258100.1; RSKR_0000258100.
DR   Proteomes; UP000095286; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   CDD; cd03365; TOPRIM_TopoIIA; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 3.30.1490.30; -; 1.
DR   Gene3D; 3.40.50.670; -; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR001241; Topo_IIA.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR013759; Topo_IIA_B_C.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   InterPro; IPR001154; TopoII_euk.
DR   InterPro; IPR031660; TOPRIM_C.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR034157; TOPRIM_TopoII.
DR   PANTHER; PTHR10169:SF62; DNA TOPOISOMERASE 2 TOP-2-RELATED; 1.
DR   PANTHER; PTHR10169; DNA TOPOISOMERASE/GYRASE; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   Pfam; PF01751; Toprim; 1.
DR   Pfam; PF16898; TOPRIM_C; 1.
DR   PRINTS; PR01158; TOPISMRASEII.
DR   PRINTS; PR00418; TPI2FAMILY.
DR   SMART; SM00433; TOP2c; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT   DOMAIN          1..110
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
FT   REGION          738..930
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          679..733
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        773..805
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        818..835
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        848..905
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   930 AA;  106677 MW;  C8FE73A4A8C2298F CRC64;
     DSAKTLAVSG LGVVGRDKYG VFPLRGKFLN VRDASHKQIK ENAEIDALLK IIGLQYRLKY
     DKEEDLKTLR YGKVMIMADQ DQDGSHIKGL LINFFHHNWP ALLKTTFLEE FITPIVKVTK
     DGRSTSFFSL PEYMKWRVDH NNGKGFKIKY YKGLGTSTSK EAKEYFSDMA KHRIPFKYGD
     EQCSVSIEMA FAKSKVEKRK EWLTSWMEER KRQRLTNEQE VYLYNENTKS ISYKQFIDQE
     LILFSNMDNE RSIPNLMDGL KPGQRKVLFT CFKRADKKEV KVAQLAGAVG EMSAYHHGEV
     SLMMTIVGLA QDFVGSNNIN LLLPIGQFGT RLQGGKDSAS PRYIFTQLSP LTKTIFKQED
     EHVLKFLNEE NQRIEPEWYC PIIPMILING TEGIGTAWST KIPNYNPRDV VENIRRLINN
     EETKVMAPWY RRFEGTMVKL GEGRYISNGR IAVINDTTVE ITELPIKTWT QKYKETVIDK
     LNDNPDKNAA FNISDYKEYH TDSTVKFVVK MNEDKLAAAE REGMHKVFQL QSIINTTSMV
     LFDSEGCLRR FDSPDEIMKD FFKCRRQKYI ERKIFLEGML QAQSDKLSAQ AKFIMAKIKG
     EIKMENVKKA EIIKKLRDLG YLPDPLKKWN DDEKKRREKE DKMDVVEEIE EEDTVVKDSV
     GDYDYLVGMA LIKLSEEEKD KLIRESKDKL TELEILKKKT WSDLWLADLD EFMAALKKHE
     DKEEAEIEKA IRDATAKLKK EAGSAKSKRG GLAAAADFKP DPRGINVVPD IQSYKDKFEE
     KPKKEKAPKK EKAPKKEKAV KKVENHGGDV SSFLVKKENG TGKKKASKKN ESDSDDTDEL
     SEFDSDDEEE NSKPRSFSKK SNTSDEEKYS KPNPKKADQK TKPTPKEAGG KRKKTESDGE
     ESKSSRNVPT RPAAKKAKLV ISSDEEDSFV
//