ID A0A1I8CG98_9BILA Unreviewed; 883 AA.
AC A0A1I8CG98;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 22-FEB-2023, entry version 23.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
OS Rhabditophanes sp. KR3021.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Alloionematidae;
OC Rhabditophanes.
OX NCBI_TaxID=114890 {ECO:0000313|Proteomes:UP000095286, ECO:0000313|WBParaSite:RSKR_0000418600.1};
RN [1] {ECO:0000313|WBParaSite:RSKR_0000418600.1}
RP IDENTIFICATION.
RC STRAIN=KR3021 {ECO:0000313|WBParaSite:RSKR_0000418600.1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A1I8CG98; -.
DR WBParaSite; RSKR_0000418600.1; RSKR_0000418600.1; RSKR_0000418600.
DR Proteomes; UP000095286; Unplaced.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd08558; PI-PLCc_eukaryota; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR015359; PLC_EF-hand-like.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF196; PHOSPHOINOSITIDE PHOSPHOLIPASE C; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF09279; EF-hand_like; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00239; C2; 1.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT DOMAIN 378..469
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT DOMAIN 467..593
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 883 AA; 100331 MW; F399017A0B43A2CA CRC64;
MSQSARAVFY NQPSVTSVSG AEILRAINDK IVVPRIKQKL KEVIASQDDE FRGRISMAEF
VDMYKDLATR PELYFLMVRY ANKDYLTTED LQLFLETEQG VSDVTKEMCE EIILKCEPSD
EGKNNSLMTV DGFTNFLLTK DSSVFDPAHL NITEDMDHPF KNYFIASSFN TYMVEDQVKG
PSSVDGYISA LKRSCRVIDL DLWDSIDIED KNEPMIHNSQ ISSCRLPLSA ALQVIRDLAF
ETTSYPLFIR LEIHMSLHYQ RLAYEMIEDI LKELIYHPIE DVRDWTDDKN VPSPKRFQNK
ILFIGKKYSS ESDVGEVIED DKSTSIMGGK KVHSPKIYIL KEFSDLIPNF LEAINVKKEG
INATDVNSLS NYDLIPKHHL VTINEGDCLR IMQNYPADLT QVIKEFITRA APDTLRVDSS
NLNPQEFWNF GIQMVALNYQ TPGLMMDLQE GKFSANGRCG YVLKPAIMRE DLFAPCDRLP
YSTQILHLRI LSGQTLPRPR GSTVKSDSAD PFVVVEIFGI PSDCAEERTK TVRNESVNPN
FDESLQFQIS VPELALVRFL VLDDDFVGDD FIGQYTIPFE CLQSGYRHIP LLNSEGDLIE
NSTLFIHIAI TNRRGGGKKQ KRGMSVKLKT NRIQTGMKQI GIKSVDELFK AAVLPLVESI
EMRNKMDYAL SNWQEQTGLN SMGTIRQGLR LMYSRINSIN TNGTPPVSTK LFHRDNTQNK
FEEHIPPSFY FEPNEVGHPV MKRRGVFPET LLKTFSSMEA LFEKCSIILS KTDSLLTKLE
EATKKIGECY EDLPDICITA GLRSQKATRA TENFAWNVRL LKSQLALMHK SQLEASDIFT
QVFDTAKLLG ILKNNNVNNI NNSNGDKLHS KAESYEDVND VQL
//
