ID   A0A1I8CHL0_9BILA        Unreviewed;       794 AA.
AC   A0A1I8CHL0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000313|WBParaSite:RSKR_0000486900.1};
OS   Rhabditophanes sp. KR3021.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Alloionematidae;
OC   Rhabditophanes.
OX   NCBI_TaxID=114890 {ECO:0000313|Proteomes:UP000095286, ECO:0000313|WBParaSite:RSKR_0000486900.1};
RN   [1] {ECO:0000313|WBParaSite:RSKR_0000486900.1}
RP   IDENTIFICATION.
RC   STRAIN=KR3021 {ECO:0000313|WBParaSite:RSKR_0000486900.1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A1I8CHL0; -.
DR   WBParaSite; RSKR_0000486900.1; RSKR_0000486900.1; RSKR_0000486900.
DR   Proteomes; UP000095286; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR   PANTHER; PTHR45638:SF1; CYCLIC NUCLEOTIDE-GATED ION CHANNEL SUBUNIT B, ISOFORM A; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        251..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        325..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        466..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          570..682
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          765..794
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..138
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   794 AA;  91298 MW;  9586AC0CAE2CF662 CRC64;
     MSGKGESSKD DRKGALQSEK HIRLSISKSI PSEPYVMSEE VKKEVFANLR QKTMIPRLDS
     FSSISMSDVS EDREFDEETL MGDHSEMNEE SLIHPQQIKE EQSDAEDILT DNEERDFNAT
     DEEKEVENDQ EDDSVSEEDI DKAPVYSSSS DSEDDDDNTK LNVPDLNTHR LSFIMQEKLH
     LFVKNVRKRT TEVREEVIKE LSSDEEDLKS VAGVEEQASL ADLLGFTEPE LKSKGFASMI
     FKDSIDSQSR LYLCWLILLV TAFLYNCFVI PMRSSYPFQT PSNIIYWKFA DYICDFIYAV
     DMFYIKPRLS FMEEGLTITK FRRTANNYIH SWTFVFDLLS LFPTDIGFLF MEQPFSMLRI
     NRAFKYPSYS ALFIILDNTV SSPYAVRIIK TFSYMIYIIH CNSCVYYTIS AYQGFGQLAY
     RMKGKFYLNR WVYNNQENAY IRCFYFTAAV ATSTGNNPAP TNVIEYIYMT GSWMMGVFVF
     ALLLGQIRDI VSNANKNKES YRVNMDLALV ICKNMNLKPE TQAKVKAWFR YTWEQQKTLD
     ERKLVDKLPL KLQADLALSV HYNTLMKVAL FQNCERALLR ELVLKLKAVI FLPGDLVCKK
     GDVGKEMYII NNGFLEVIGG ENNEIVFATM AVGTVFGEIS LMAIGGNNRR TATIRSKGYS
     TLFVLSKEDL NEAIKDYPEA QRLLKKKAKQ MLKKDQKAKV KNTEEVEKKR MEEKCKVTTE
     IKTPKMFTTI ANAVRPGSAI SKRMAEVLET DKVEKKNRHW STLQSDSDLS DLDMPLPIND
     GDMRNIKSPL TVKK
//