ID A0A1I8CJE6_9BILA Unreviewed; 618 AA.
AC A0A1I8CJE6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Phosphatidylinositol 4-kinase beta {ECO:0000256|ARBA:ARBA00039877};
OS Rhabditophanes sp. KR3021.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Alloionematidae;
OC Rhabditophanes.
OX NCBI_TaxID=114890 {ECO:0000313|Proteomes:UP000095286, ECO:0000313|WBParaSite:RSKR_0000498300.1};
RN [1] {ECO:0000313|WBParaSite:RSKR_0000498300.1}
RP IDENTIFICATION.
RC STRAIN=KR3021 {ECO:0000313|WBParaSite:RSKR_0000498300.1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00036767};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19878;
CC Evidence={ECO:0000256|ARBA:ARBA00036767};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}. Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004450}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00037860}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037860}.
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DR AlphaFoldDB; A0A1I8CJE6; -.
DR WBParaSite; RSKR_0000498300.1; RSKR_0000498300.1; RSKR_0000498300.
DR Proteomes; UP000095286; Unplaced.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 319..603
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 618 AA; 71180 MW; BF33F3F4573BC73E CRC64;
MNRSYVQEPS EYCFHPKNGV CPRCSLKASF VIDDEEEENK VVVGQVIPVE ASACSLFRFF
ESNYFTIHHA MHYLQSSVDA SALPKLGETL YKFPKHCVDF YLPQLMILYV NKHNVAECLH
SYLMDRCKSS IEFCVTCCIL LESFNTENWK LNKLACQGFK LRKQILNIFY RDGFSYDQIT
FRNPSIQSLQ LNSCECIEEF ELPQSNLFHL MKFVCDCGMK KVRPEFEFIQ SLIAIGTDLK
ELAPGVERNE RLTTHIQDIN AFLPGRVWVP LSGLPLDVSN MTIEQLRQKY IKDNDEDDRG
EESEFGEIGV DQKVLQESEV GQSSIFSESW SHIYSKIKAI STYSFLPNWT VLPVIVKTGD
DLRQELIAYQ ILTLFEEIWT DERVPLYLNP YKITVLSQDA GLIEPIKNAQ SLHQLKKTLI
GDNESGVAPT LLEYFIDKYG KEDSVGFKKA QQNFVRSCGA YSLICYFLQV KDRHNGNILL
DEEGHLIHID FGFILSQSPK NLGFETSPFK LTPEIVDLMG GAFGKPFEEY KTLMLRGMIA
ARKHHDRIMT LMQIMTSNCE IPCFRYGCSL VEGMLERFHV QYTDDELHQL IFNMVEASRG
SITTRLYDNF QYYTNGIM
//
