ID A0A1I8CJT6_9BILA Unreviewed; 511 AA.
AC A0A1I8CJT6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=inositol-3-phosphate synthase {ECO:0000256|ARBA:ARBA00012125};
DE EC=5.5.1.4 {ECO:0000256|ARBA:ARBA00012125};
OS Rhabditophanes sp. KR3021.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Alloionematidae;
OC Rhabditophanes.
OX NCBI_TaxID=114890 {ECO:0000313|Proteomes:UP000095286, ECO:0000313|WBParaSite:RSKR_0000530000.1};
RN [1] {ECO:0000313|WBParaSite:RSKR_0000530000.1}
RP IDENTIFICATION.
RC STRAIN=KR3021 {ECO:0000313|WBParaSite:RSKR_0000530000.1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC EC=5.5.1.4; Evidence={ECO:0000256|ARBA:ARBA00000113};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 1/2. {ECO:0000256|ARBA:ARBA00005117}.
CC -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC {ECO:0000256|ARBA:ARBA00010813}.
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DR AlphaFoldDB; A0A1I8CJT6; -.
DR WBParaSite; RSKR_0000530000.1; RSKR_0000530000.1; RSKR_0000530000.
DR UniPathway; UPA00823; UER00787.
DR Proteomes; UP000095286; Unplaced.
DR GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11510:SF5; INOSITOL-3-PHOSPHATE SYNTHASE 1; 1.
DR PANTHER; PTHR11510; MYO-INOSITOL-1 PHOSPHATE SYNTHASE; 1.
DR Pfam; PF01658; Inos-1-P_synth; 1.
DR Pfam; PF07994; NAD_binding_5; 1.
DR PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Inositol biosynthesis {ECO:0000256|ARBA:ARBA00022550};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 306..419
FT /note="Myo-inositol-1-phosphate synthase GAPDH-like"
FT /evidence="ECO:0000259|Pfam:PF01658"
SQ SEQUENCE 511 AA; 56533 MW; 8E76E5933C2F1122 CRC64;
MKINVENANF VIGDGYGTAQ FEYKKNEITR EGDAIKISPK SHNYTFKTKM APTKTGLLLV
GLGGNNGSTV MGSIIANRLA MNWETRNGLK SANYFGSITQ ATTVHLGWDG KKQIYAPFNS
ILPMVTPNDL IVGGWDINSA NMYEAMQRSR VFEPELIAQL RPYMENVTPM PSIYYADFIA
TNQEQRADNV IPGDETQKQK HLEAIRKDIR DFKQANELET VIVLWTANTE RFTDVKCGFN
MTAEEVMESI KNGAAEISPS NIFAVASILE GAHYINGSPQ NTLVPGIIEL AQRHNVFVGG
DDFKSGQTKF KSALVDFLVN SGLKPESIVS YNHLGNNDGK NLSEARQFRS KEISKSSVVD
DMVEANTILY PDGKKPDHCI VIKYVPYVGD SKRAMDEYIS SIFMGGQQTL VIHNTCEDSL
LAAPLILDLA IITELCTRIQ YSTVATGNTF EHFHSVLGLL SLMLKAPVVP NGSPVMNAFM
KQFNSITKLL TICAGINSDT DLQLEFFTKT E
//