ID   A0A1I8CLL4_9BILA        Unreviewed;       423 AA.
AC   A0A1I8CLL4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=isocitrate lyase {ECO:0000256|ARBA:ARBA00012909};
DE            EC=4.1.3.1 {ECO:0000256|ARBA:ARBA00012909};
OS   Rhabditophanes sp. KR3021.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Alloionematidae;
OC   Rhabditophanes.
OX   NCBI_TaxID=114890 {ECO:0000313|Proteomes:UP000095286, ECO:0000313|WBParaSite:RSKR_0000591100.1};
RN   [1] {ECO:0000313|WBParaSite:RSKR_0000591100.1}
RP   IDENTIFICATION.
RC   STRAIN=KR3021 {ECO:0000313|WBParaSite:RSKR_0000591100.1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- PATHWAY: Carbohydrate metabolism; glyoxylate cycle; (S)-malate from
CC       isocitrate: step 1/2. {ECO:0000256|ARBA:ARBA00004793}.
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DR   AlphaFoldDB; A0A1I8CLL4; -.
DR   WBParaSite; RSKR_0000591100.1; RSKR_0000591100.1; RSKR_0000591100.
DR   Proteomes; UP000095286; Unplaced.
DR   GO; GO:0004451; F:isocitrate lyase activity; IEA:InterPro.
DR   GO; GO:0004474; F:malate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   CDD; cd00377; ICL_PEPM; 1.
DR   Gene3D; 3.20.20.360; Malate synthase, domain 3; 1.
DR   Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR   InterPro; IPR039556; ICL/PEPM.
DR   InterPro; IPR006254; Isocitrate_lyase.
DR   InterPro; IPR018523; Isocitrate_lyase_ph_CS.
DR   InterPro; IPR011076; Malate_synth_sf.
DR   InterPro; IPR048356; MS_N.
DR   InterPro; IPR046363; MS_N_TIM-barrel_dom.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   PANTHER; PTHR21631:SF3; BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN; 1.
DR   PANTHER; PTHR21631; ISOCITRATE LYASE/MALATE SYNTHASE; 1.
DR   Pfam; PF00463; ICL; 1.
DR   Pfam; PF20656; MS_N; 1.
DR   SUPFAM; SSF51645; Malate synthase G; 1.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR   PROSITE; PS00161; ISOCITRATE_LYASE; 1.
PE   4: Predicted;
KW   Glyoxylate bypass {ECO:0000256|ARBA:ARBA00022435};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT   DOMAIN          296..355
FT                   /note="Malate synthase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20656"
SQ   SEQUENCE   423 AA;  47476 MW;  7829264C945B29D2 CRC64;
     MNHKLGITEA GFGGSLNCYE LARNYIEAGV AGIHFEDQLG SEKKCGHLGG KVLIPTSENI
     RHLNAARLAA DVCGTPTLIV ARTDAESARL LTSDIDPRDH EFIDYKKGRT AEGFYQLKDS
     NYMESCISRA ISYSPCCDLI WMETSKPSLS EAREFVEGVR AVYPDKLFAY NCSPSFNWKQ
     HLKVSAMENF QSELGKMGFK YQFITLAGYH ANSFSIFDLA RGYKSQGMAA YSELQEKEFA
     NEKNGYTATK HQREVGTGYF DKIASTISKN SSTTALAGST ETAQFQTSVE DEEVVTLTAD
     LGPSEDKVLS PDALRFLRDL HYQFEHRRLD LLEERKKVQG KLDDGSFFPD FSPKTRDIRE
     DMSWKGAEIP KDMLNRKVEI TGPTDRKMVI NAFNSGAKVF MADFEGNKNV LIIFNVIKIP
     THR
//