ID A0A1I8CTH6_9BILA Unreviewed; 2434 AA.
AC A0A1I8CTH6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Protein-tyrosine-phosphatase {ECO:0000313|WBParaSite:RSKR_0000831500.1};
OS Rhabditophanes sp. KR3021.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Alloionematidae;
OC Rhabditophanes.
OX NCBI_TaxID=114890 {ECO:0000313|Proteomes:UP000095286, ECO:0000313|WBParaSite:RSKR_0000831500.1};
RN [1] {ECO:0000313|WBParaSite:RSKR_0000831500.1}
RP IDENTIFICATION.
RC STRAIN=KR3021 {ECO:0000313|WBParaSite:RSKR_0000831500.1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR WBParaSite; RSKR_0000831500.1; RSKR_0000831500.1; RSKR_0000831500.
DR Proteomes; UP000095286; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 7.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF00702; Hydrolase; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SFLD; SFLDG01129; C1.5:_HAD__Beta-PGM__Phosphata; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1400..1424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..126
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 138..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 279..364
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 371..467
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 472..568
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 572..662
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 671..773
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 776..873
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 969..1073
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1567..1828
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1748..1819
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1860..2098
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 2033..2098
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 2434 AA; 275782 MW; C4C83288FA0D63FF CRC64;
MKRRKTGLRF GTSSLYCLYI ILMYAVVFVT PKNDAPKFVV KPDSSTVLEN SKVSFFCRAD
GNPLPSILWR ILNENVNNPR YTIKTLQNGF STLRIDPVLM SDSNLTLSCV ADNGVRQPIK
ADVVLTVLNA NHFPESFPKV ESHPIMKSVE QGKTAHVSCR VTGNPRPKIL WLRDLMPIDI
RTSSRYSVST LGNPGALMIQ QAREEDQGKY ECVARNSYGV VHSQAAQLYV KVDSFIFQHA
VPNKVFHEAQ KLALDYQRWE ALNDTHLVGQ IEDVRRVPPY FSYKLEKVYQ VLKDGNINLT
CVAVGYPMPR VFWKRQSDEV LLNDPQTAPI GKNVLKLTNV ESSVNYTCIA VSKLGNIEAT
TTVLVKPVPE PPHGLTVINI NSTFAILQWK NIRSDEDNLL ITHYILRYRE KFSTEKQFIE
KVVGKNETNT IIDHLSPYTQ YEVMIASGSL LGIGRFSFPL EIETDESLPA NSPENVHARV
INEDSLMVQW DPPETPNGKI IENIIYYTNK NEDRNVSEWE YFKVRDSKNT ATISDLTPED
TYHIRVQSKN SRGYGPISKS IAVITKQGIP GAPDHLKAAA LENNRISLAW DKPRHSFNIQ
GYVMVYNMSE NDYNEVQLGE KLNKHIMENL KPSTKYSFRI AAKSPRGMGA FSNMETISTA
KNDYNAYVPP EPENVKVEAV NATTVSVTWK EPFGYTGTIL GYNVYKEKLF NGEPVDNKLQ
KAVSIYPKEQ LHALITDLIP NTEYSFRVNA ENKFGDGRHS DAVKIMMEGL PPSAPIIQSL
SLIREETPLA ARLEWLPPKE MYGKSVTKYH LWYRPDIHTE YSRIDIPGDS RSIEVKDLIK
FREYIFILAA ATVDGVGLNT TESLSTPAGI PDSPPLNVRY DIVKGKIIFA WDPPPLDQQN
GNITYYRAMI TSESRKPLIK NVTNANSIAL PMTVKSTSTF KVAAGTVSGL GPESAGLIVY
PDASASVSAP TNVRVEATSN SSVVVVWDFD SKNYDSAADG FVVKYIHEPP SGAGNTDFER
WKAQTIMDPK ARHIEISQLT AHKPYAFCIL TVKQSRQGPC SDPPVTIAQL KPHYIATNLR
VEYKTSTSVS LRWDYAGESN IEFYVNHTSR KYYLDHNLEY KEMVSPVFRK FLKGTERSIL
WDNLRPYMEH TFKVGVKVVE KGQDVFYWPR EIVVQTDNTG PPFVDKPEFL ESLSPHTATI
RLKCASEEYG PISKYWIVVV PGNFTQETIN NLDSQVLKHH SEQLKIQFDR DGYSMKQEGA
SHMKKVKRSH QNTSLIDRRV IRPRTTRFAG GPLPTIPYVT AEISAQRMQT MQKEKETFTI
GDGKNYDGFE NFPLHPSSHY KLMMRAFAKD LENGKKNGGP FTYRAPMNQP RAKKYADSML
TTDFSTKLTP INKLSKSSSL WLVGPIIAVI IITLILGLLV IWWWKFSKKN PSHLGNRHGS
ITKVALADSG NGNIPNETSK LLFGQDAYGR PIINAYDMHQ NGNIHHNVME SSLIDLHTTA
NQMCDGSSMA YKVHNAHVPV LYEPYDNYQD LQMPVQILSE MKKRTPIAIS DLSSHIDQLK
MHNNQLFTSE YDSIEKSAPN LEWKTSTIPY NKTKNRYANV VPYDETRVVL KSIYGIEGSD
YINANYIDGY HQERAYIATQ GPLPETFNDF WRMVWETKSY MIVMLTRLEE MSRIKCDQYW
PQRKQRYGMI QVELLDTIQL AHYTVRTFRL QLISEHNPNE IIQSRDIKHM QYTSWPDHGV
PDHTTPFLMF LKRVKTLNPQ RAGPIISHCS AGIGRTGAFI VIDCMLERLR HENTVDIYGC
VREIRAQRSY MVQTDDQYIF IHDAVLDAVQ SGSTEIPAKS IYHHIEVLTT LHALDHSSGM
DLEFQTLGRL RVLKGETEVA TLPINRSKNR SSTIVPYDSS RVVLKMINGY ENSDYINASW
IDGYRSRNMY IATQSPLQQT AVDFWRMIWE TGSSIIVMLI NSKELEKDRC YVYWSIETTE
QYGNLEIERT NEYAVDNYSM REFKVTYLKS VSKTVRLFQL LDWPDNGVPR SADPFIKLVE
LVHESYQTFG LTGPIVVHDH LGTGRAGVFI AVSIIIERMK LEHVVDVFTT VKLLRTNRRQ
PNEIKAVKKK NIMLLSKAAR TIVFKTSSFS LRNQRANVKN LIKRCQLSTL VPEQNPQLSQ
GNSSSVTTTR PNPDFVTVHS MLDESRLMLP KTSLVIFDKD GTLICFHAMW IPWVTNFALR
IEELVEKKLS PAIYSRLGYD PKAQKVLPGL LAEATMKEIR EATENVLVEH GVSPPLAINV
VEKVSAILSE DRSSNHIKEV ADLRELFLTL RMNGILVAVC TSDSRQNTEY TLKALNLNGL
VDFVRCGDDI DSLPKPHPSN AFAICNALNV HPSETLMVGD TLTDLRMAKL AKLGGSVGVL
TGVGNRDLLQ KHSTLLIENV AQLLSYLPNI AIHY
//
