ID   A0A1I8CYH0_9BILA        Unreviewed;       595 AA.
AC   A0A1I8CYH0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00012699};
DE            EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
OS   Rhabditophanes sp. KR3021.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Alloionematidae;
OC   Rhabditophanes.
OX   NCBI_TaxID=114890 {ECO:0000313|Proteomes:UP000095286, ECO:0000313|WBParaSite:RSKR_0000993900.1};
RN   [1] {ECO:0000313|WBParaSite:RSKR_0000993900.1}
RP   IDENTIFICATION.
RC   STRAIN=KR3021 {ECO:0000313|WBParaSite:RSKR_0000993900.1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC       {ECO:0000256|ARBA:ARBA00004760}.
CC   -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC       {ECO:0000256|ARBA:ARBA00006739}.
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DR   AlphaFoldDB; A0A1I8CYH0; -.
DR   WBParaSite; RSKR_0000993900.1; RSKR_0000993900.1; RSKR_0000993900.
DR   UniPathway; UPA00222; -.
DR   Proteomes; UP000095286; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd02520; Glucosylceramide_synthase; 1.
DR   Gene3D; 3.40.630.30; -; 1.
DR   InterPro; IPR025993; Ceramide_glucosylTrfase.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR   Pfam; PF13506; Glyco_transf_21; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        214..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   595 AA;  68695 MW;  BDA1A06C9D2171B5 CRC64;
     MILAKLIRTN VTSRLPLERA FFTPTTTYEI RSSTQNDRDK MVDMLSNEFH DDEPITQLLK
     LSRKVMRPTY EHILKSKLYM DNSFCAFTQE DEMIGIFICG IKSTLPKYKS LMGKEDDTFY
     ENYIRKHPET YPLFGVLGKC KEDYWNDNPR IHTMVRSDIM VIKEKHRGMG IAQKFNEKMF
     RVLRERYPEL QGVIGEWPWN LLRFFDNLPD NTSFLNLLSI AILLFVGGLY VLHLISFFYA
     KYRLHKPCQP SSKKIGVSII KPLVGVDNNL EQNLESFFQL NYLNYELLFC LNDAKDSAYP
     IVKKLCKKYR NVTSKIYLGG EFVGLNPKIN NMMPAYRNSI NPLVLVSDSG MYMRPDALTD
     MVACMKDSYA LVTQQPYCKI REGFGANLEM VYFGTAHARI YGAGNCLGFT CSTGMSSLMR
     RKALEECGGL EAFSPYLAED YFIGLAFANA GYGSSISHLP GLQNSCITEM KAFNDRISRW
     IQLRTRMLIH TILLEPIQEC FLSGFLSAAA INHLFGVNYC VYFVGHVAYW CFWDYVLFNI
     VENGKLPFSI SKFLLLWTCR ELLAFPLYLR ALFNSKIIWK TGTFQLEWGG RIRKV
//