ID A0A1I8E8H1_WUCBA Unreviewed; 575 AA.
AC A0A1I8E8H1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=WH1 domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_1013-snap-gene-1.28-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-PairedContig_1013-snap-gene-1.28-mRNA-1}
RP IDENTIFICATION.
RC STRAIN=pt0022
RC {ECO:0000313|WBParaSite:maker-PairedContig_1013-snap-gene-1.28-mRNA-1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A1I8E8H1; -.
DR STRING; 6293.A0A1I8E8H1; -.
DR WBParaSite; maker-PairedContig_1013-snap-gene-1.28-mRNA-1; maker-PairedContig_1013-snap-gene-1.28-mRNA-1; maker-PairedContig_1013-snap-gene-1.28.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd00132; CRIB; 1.
DR CDD; cd01205; EVH1_WASP-like; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR033927; WASPfam_EVH1.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR11202:SF36; NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00568; WH1; 1.
DR Pfam; PF02205; WH2; 2.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00285; PBD; 1.
DR SMART; SM00461; WH1; 1.
DR SMART; SM00246; WH2; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS50229; WH1; 1.
DR PROSITE; PS51082; WH2; 2.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 51..163
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 243..256
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 471..488
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 501..518
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 224..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..351
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..380
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..412
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..461
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 62841 MW; DEDF2E1E609E5A86 CRC64;
MYTCGTPTGA YQIGVQHVGL NMTPTGRPKK RPPNTGALLF NSVENGTLFS LLGHDCVSLA
AGVVQLLKSD PRNPGVWIKA HRGVVSLVKD YDKRAYFLRL YDIYRKQYLW QQMLYKNFHA
SQPLGCPHLL TFEGDECVFG LNFSSKEEAF SFKSHLDKRY EQERKSQEKE KMVTSGSQNI
SGSLLPFGGR THAVSTPHRT GITSMGTVPN IGGGTWTNFV TINRTKKKSS KKEKKQKIRK
EDISNPTNFQ HKAHLGWNQD GGFSQETYNY DPMDDSVKAV LRAAGENPER MSKDDLEFSK
KFITGYQEVP KVQQPPAPMH HNYQRPFMTS SIINSPALSP VPPPPPPLLR REGFHITPVS
RPPLKPPASS KPPARPLPQP PGAMNGTSTT YRPNDVPPPP PPPPPPSSST YSLPTAAPPS
SVSTNSSLAP PPPPPPPPPP PPVTCASGTI PPPPPPPPSY TSTASNGGGR GKASLLSEIQ
AGVTLKQVTA NTNHDNSITD ARDEMMAQIR QGANLKPVDK EEIENRKSVP NSTDVAGIAG
ALARALEERR RNIRNSDESE SEEEANNNDS EWESD
//
