ID   A0A1I8EAZ3_WUCBA        Unreviewed;      1069 AA.
AC   A0A1I8EAZ3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE            EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_1260-snap-gene-4.31-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-PairedContig_1260-snap-gene-4.31-mRNA-1}
RP   IDENTIFICATION.
RC   STRAIN=pt0022
RC   {ECO:0000313|WBParaSite:maker-PairedContig_1260-snap-gene-4.31-mRNA-1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001171};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   AlphaFoldDB; A0A1I8EAZ3; -.
DR   STRING; 6293.A0A1I8EAZ3; -.
DR   WBParaSite; maker-PairedContig_1260-snap-gene-4.31-mRNA-1; maker-PairedContig_1260-snap-gene-4.31-mRNA-1; maker-PairedContig_1260-snap-gene-4.31.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd00064; FU; 3.
DR   Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR032778; GF_recep_IV.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF14843; GF_recep_IV; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   SMART; SM00261; FU; 6.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR   SUPFAM; SSF52058; L domain-like; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          26..139
FT                   /note="Receptor L-domain"
FT                   /evidence="ECO:0000259|Pfam:PF01030"
FT   DOMAIN          158..311
FT                   /note="Furin-like cysteine-rich"
FT                   /evidence="ECO:0000259|Pfam:PF00757"
FT   DOMAIN          355..477
FT                   /note="Receptor L-domain"
FT                   /evidence="ECO:0000259|Pfam:PF01030"
FT   DOMAIN          511..598
FT                   /note="Growth factor receptor"
FT                   /evidence="ECO:0000259|Pfam:PF14843"
SQ   SEQUENCE   1069 AA;  122104 MW;  1B5AC646774E859E CRC64;
     CSGTDNSRTE LQDKNRINQL IRQYQNCTRV YGNLELTYIR HEDLNGTDPE RFFSFLDHIQ
     QITGYLLIYS NDFDQITLRN LEIIWGDTRH DEIAAIDISY NDNLKYVNMP KLRSVERGNI
     VLMHNPYLCN WNTTVSYNEI IGKASELRIQ FMNNFGKCDQ AQSRCAEKCG KYCWGPNTDM
     CQTVYREICP KSCPSQMCYQ DDNRTHCCDE ACAAGCFGEG KSACIACAKL EQDSKCVDKC
     NGLTDYDRKL KMTVNHSNPR YTYDRYCVER CPGETLIQGE YCVVHCTEGY WHDPVKNTRV
     CEKCPDGICP KSKIFRIFPG NDDWLHIYIY IYIYIYRTCY MNEPIDSSNI RSLANCTVVE
     GFIQILRHTF DSHRKFFTDG RPPIYIRGLT VEMLEVLKNV KVITEFVEIQ AADCSPPSLS
     FLGNLTTIEG RKLSNQRYAL LITSNQNLFE LGLRSLREIR NGRIYIGRNE KLCYVDSLKE
     YWKKIMQTND TSRLILADKN SIYCIRNKKF CHHTCNKIYG CWGEGPKMCI KCIGYSVDGE
     CSATCPPERY YIKDKKCHKC HPQCKSCNGP TARDCIACMN VRIQQRNKWE CMMECPKTHY
     VDGNTCLPCN VACYNFGCTG ASNILGKGGC NKCKHAKRSD SGKLPLCLYA TGKPKDVCRD
     NNLIRYYATA SSNEMLVAEF ECDECSEECL SCSGYGTSVK RHKCTCAHYL TKTVSNNDYC
     TMKCKMDSFM VRPRSGSTIG ECERCDELCD FSMGCTGRSS TNCTRCAKAG ISKGNKLTCL
     ERCPDDHPFI AEDKICHVTD PTAYALKNVL CAAVLIAFIA GITINCVKYK KRYQKELEMN
     LPSIPEYEQT DPSMRPNMTR LCIITSENLE KTQQSLGQGA FGTVFLVGYK IRNRDQDRYY
     KQQLESALLG NQRELFNGLV DNEELSDQFK FSGGTTATST SVPPSPMTPS WVPFQQDALN
     IQQDKRLGST DSGRYQSDPV HDGHTKLSMD EGNYLVPNNK QLILYTPVVV RENGETEVMK
     SSEYYNDKVG TDYYNQLKSI SMEMEKETKS IKITTYQNDY YFAENETSL
//