ID A0A1I8EB58_WUCBA Unreviewed; 1290 AA.
AC A0A1I8EB58;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=SAP domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_1260-snap-gene-4.29-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-PairedContig_1260-snap-gene-4.29-mRNA-1}
RP IDENTIFICATION.
RC STRAIN=pt0022
RC {ECO:0000313|WBParaSite:maker-PairedContig_1260-snap-gene-4.29-mRNA-1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR STRING; 6293.A0A1I8EB58; -.
DR WBParaSite; maker-PairedContig_1260-snap-gene-4.29-mRNA-1; maker-PairedContig_1260-snap-gene-4.29-mRNA-1; maker-PairedContig_1260-snap-gene-4.29.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR045354; BURAN.
DR InterPro; IPR025224; CCAR1/CCAR2.
DR InterPro; IPR025954; DBC1/CARP1_inactive_NUDIX_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR045353; LAIKA.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR025223; S1-like_RNA-bd_dom.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR14304; CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN; 1.
DR PANTHER; PTHR14304:SF11; SAP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF19257; BURAN; 1.
DR Pfam; PF14443; DBC1; 1.
DR Pfam; PF19256; LAIKA; 1.
DR Pfam; PF14444; S1-like; 1.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM01122; DBC1; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 624..658
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 892..927
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 142..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1023..1078
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 267..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1290 AA; 145313 MW; 66E281B4BC8BBAA2 CRC64;
MSQFGPKNPA AWARPPGANQ QLNAGLFQNP LIGAQPFAQM GMINAAAFSQ QAVGNMGMNL
GMLQTPSQTI RMQAQQQQKN RTFSGVVTKM HDNYGFIDDD VFFQVSNVRG ALPRTGDRVM
VEASYNPTMP FKWNAYRVQL IGDKGGPGGG GPPTHTPPDR GRQPITGRGM IPGEQSWAGK
TLEKPQAVTH INDSRSPPRS RSPIGPGRHR SPRGGQCGPP ALVQDMRRLS SPRRISPPRG
LARRSPRRSP PRDYSKGQMG RISPKHSTPA RKHEGKREHS ASVSGRNRSP SQKHDPSTHD
SLSPPRRRSR IIPRYQCYIP KPPILNGTRQ TVMQLRKRYP LLYIPSDFSD ISIEWPKTTP
IENPISISTA PITYHILHKD IDCPSENLHA LNPPDADCRF SVKVVLMSHQ GLSLVHQKAF
GLLVDGSIDE NVDSASLKRC LNFVVGTRNK EMMAVGGAWS PSLDGDNPET DPQVFVHTAI
RTVRTLIGVD LSRCPRWYIR YYRAEKDRMD TCCLFLPDTS GLMPTEDCYQ QLLATLKDQL
GNKLAAIDAQ KLVLPSTVAA TATDCGDAGE GTTVTTEPTA PTGDTQQQLQ QGQQQSDANK
EQVQEVEEED DEDLNPTHWS KLDIRTMKVA ELRQELMARD LETKGVKSVL CARLQEALDQ
EKTKDEDKED VCLKTLAVGM VEVAKPQEEN EEKQLTVEDK KAIEKSEKEK KEKKASLELA
KPQEENEEKE LTDEDKKAIE KSEKEKKEKK ASLERHFTIP KEPGILVYPN RMAKGGKFDC
KIVSLHTMLD YRIEDNKEHS FELAVMAECI SEMLDRSQAF IAYKTLSRAI DKESEKKRRE
EAKLAEVIGA EEGTESVKAD KTEKPEEEKK KEDEKKEEEQ RKSLVEARKP IIIDRTVFQA
FAHFDQNLCG YILEKDFEEI LFSIGLNISR AQVQKLLKRY LSRDRISYRY LTDSWANKDG
TVTYRPGVIS DPPTTEQLTK GNMSKESIDA NKKTTSEAPD ISATGSVIYL GSLMNIPQVL
EQVSKMESDS NAALQKVDVL EAQLKDGAKH VQVLEKKKKR LEEDVEKYRK RLHDAEKCLK
NSVDDTVQMK SAIQEFRRIG ERMIGMAEKL MPNPKEEEKT SEKDEKDVKK EKKDDKDDKK
VPKKKDSALT KVNGEAEEKK ELQLVDEVGG NDVGDEPMES DVIVLSEEVT GDEEKDVKKE
ILSSQKTDST TETVESDTVT SLTFPNWGGS TWTERFRKLL AIISYFLVRA KFLNRSKMPR
CGGTYILLWP HLGHQEIILD RYWSYMNCCE
//
