ID   A0A1I8EDP1_WUCBA        Unreviewed;       506 AA.
AC   A0A1I8EDP1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Homeobox domain-containing protein {ECO:0000313|WBParaSite:maker-PairedContig_1613-snap-gene-0.24-mRNA-1};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_1613-snap-gene-0.24-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-PairedContig_1613-snap-gene-0.24-mRNA-1}
RP   IDENTIFICATION.
RC   STRAIN=pt0022
RC   {ECO:0000313|WBParaSite:maker-PairedContig_1613-snap-gene-0.24-mRNA-1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC       ECO:0000256|RuleBase:RU000682}.
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DR   AlphaFoldDB; A0A1I8EDP1; -.
DR   STRING; 6293.A0A1I8EDP1; -.
DR   WBParaSite; maker-PairedContig_1613-snap-gene-0.24-mRNA-1; maker-PairedContig_1613-snap-gene-0.24-mRNA-1; maker-PairedContig_1613-snap-gene-0.24.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR031701; SIX1_SD.
DR   PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR   PANTHER; PTHR10390:SF33; PROTEIN OPTIX; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF16878; SIX1_SD; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682};
KW   Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682}.
FT   DOMAIN          171..231
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        173..232
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          217..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          367..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          452..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        481..500
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  56460 MW;  C317657FB7E6D10D CRC64;
     MSGLLGAEQL QKLWMHVALN SMQGYPQGNS LYPPLRPFAF GTMLQPETSM FTGEQIVKIC
     EQLEDAGNIE RLAAFLWSIS HQQHTDEVTT VLRNHESVLR ARALVCFHMG NFQEMYRILE
     SHKFTNGSHS KLQAMWQEAH YQEAEKLRGR PLGPVDKYRV RKKYPMPRTI WDGEQKTHCF
     KERTRSLLRE WYLQDPYPNP SKKKELASKT GLTAMQVGNW FKNRRQRDRA AAAKNKANEL
     NGVKRSPESD NSEDSEMEED MFDSSLLADS PTPSEECGST EKSQHSAACA SLTATKMPAE
     PSLPHPIDVA SSTTMFGAAS TFDPLQFDPL RMLMNRSLNA GVLNPILAQP AAMLSLQQQL
     SKHISSTSVQ PNLKANPSCG IKQHETGRTE TSSNIKISLD RKRNANCGNN SSSISTTPKR
     SKLLIDEILN LKSNETYSAD AHDTVTDGSL QQENFSSHST SREHSVEPNL TKEDGKASIS
     DNGVMTDTLS VVPADSSNSR RSSETR
//