ID A0A1I8EDX7_WUCBA Unreviewed; 1603 AA.
AC A0A1I8EDX7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_1625-snap-gene-1.8-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-PairedContig_1625-snap-gene-1.8-mRNA-1}
RP IDENTIFICATION.
RC STRAIN=pt0022
RC {ECO:0000313|WBParaSite:maker-PairedContig_1625-snap-gene-1.8-mRNA-1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR STRING; 6293.A0A1I8EDX7; -.
DR WBParaSite; maker-PairedContig_1625-snap-gene-1.8-mRNA-1; maker-PairedContig_1625-snap-gene-1.8-mRNA-1; maker-PairedContig_1625-snap-gene-1.8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 735..850
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1220..1493
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1393..1466
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1603 AA; 180732 MW; 505140A39C69918D CRC64;
MKPNLDFREI FSDAVGTIIA HFTVVIARAV IYSEVIKLKN VLKKFLKYYF IFHLISTANS
QFSFNWVSFQ NGLGNTSSVA PYQEILNEEL YIKTLRGDPR STTFVIDDSV LVDTTNKSQV
FHKSKSIRSR QLFQRSLSTL PDFSIEKSPR DRSTLLTVIL PRSPTNFGQF IAKVVDISPV
VNLSERDINR TFLASPSDFK TISIHSLHPG HQYSVTVIGR RKGESQLIKE ERVITDPVAP
DFASPNASVL SFHTNITLRA LKPEKALQDS YQISYVQLDP LRHFPKLEVN DIPEQRYIEI
YLGNLMPGQN YNVSITPQIK DVEGRPWNGI LTTKNLTVTE LNTSCLRLSW FLTSRTGADS
ISIGYRLDKT NSPLTEVRSD LGNFTSKFCE TLEISHYSKN SETSDDVKLL YTVKPKAPEN
LKILTDYEKR KFRLVMDIAP ESESYVEKCF VSLVNEKLDV VEKLSSVDSS NSTSAARECS
IYVDLYPGQR YEVSAKTISE NASSNIISKS FALQPAFDME TFGLQLSESD GTLMLKWPVA
EMAQARLDDV WENIVGPDST LHLRVDPLSK SMWQEQSKRF ERRQYERDPL TIPKLRRGAC
YRVQIYTVTK SGIASAQKFE EFLRISAPKV NITAKEIAKS TASFRAILES PVIFDPPECN
LHIVVLDMRN ITIYDRTTPL TPEISPVVLE GLQPYHRYII SSQVICGKVN DMSCLPKLRA
MEPIFFETRQ DRPGPVRSLM VRILNPYSVQ LFWLPPSLPN GIITHYIIGI HSMEDDREDD
WSVSVGAAVN SPPLSFHDNN TKTNNKQQPI EAVVDNLVGG LRYRMDVRAV TEAGEGDYSA
VSDTVHVEMP ILPPPRPSSR IEIVYNTIHS TDMGIRYSTS MFNTKHGYLK KSALIVAEVS
NNSENIINSI IDGQNKTLTW GQAQQFDLWP AYVAVETTIE PLRKFIPPHF VSEIIGADGT
CGDIEVDTIC NGPLKPATSY RFKLRLYTSP DMWTDSEYSE IATTKASPTL FTLGSVTTVL
PRIYGSQQHP YTYSQQFLGS VGEREDREVT RIGIGILRPN FAYSTSATNQ HKQEQNITGD
GEVFSHWAVL KMIMAERAAQ CLAKLGLNTA TTTATSTNIL HSQISQPQNI ITTTDSTTIV
SAKPNDLVTT SGHHRRSRSL RERTGVDQRL ERLPSGPVTL QKFTPHTVIP ESNIDKSRPV
LVNNFAEHVR LMSADSDFRF SEEYEDLKLV GHGQTCIAAD LTVNRAKNRF TNILPYDHSR
VKLTPTDDDD GSDYGFNSRR EFIAAQGPLP STRDHFWRVV WEQHCPAIIA LTKCVEKGRD
KCHQYWPDND QLSVLYADIE VTLMNETVYK EFTVRELKLT NISEPVAPSR TVKHLHYMAW
PDFGVPEYAA GLVRFVRLFR TRLPPSPSNK PTVVHCSAGV GRSGTFIALD RLMQCAAKNL
PLDVFGIVYE MRLDRCHMVQ NEVTFFYFCF PFLPFRQHRR QQYIFIHHCL LYVLETQYDM
ATNLIGNSLS QVGSNQGTTT SAFLSDNVVI DFPNSITSND VGNNLNAGIT ENDVQIICSN
GSTTFIGTAL QHQPNTTWIT TPRVEVHLNP AFDDDEGIAE SGL
//
