ID   A0A1I8EFQ1_WUCBA        Unreviewed;       375 AA.
AC   A0A1I8EFQ1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=sphingolipid 4-desaturase {ECO:0000256|ARBA:ARBA00012021};
DE            EC=1.14.19.17 {ECO:0000256|ARBA:ARBA00012021};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_1872-snap-gene-0.9-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-PairedContig_1872-snap-gene-0.9-mRNA-1}
RP   IDENTIFICATION.
RC   STRAIN=pt0022
RC   {ECO:0000313|WBParaSite:maker-PairedContig_1872-snap-gene-0.9-mRNA-1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family. DEGS
CC       subfamily. {ECO:0000256|ARBA:ARBA00006146,
CC       ECO:0000256|PIRNR:PIRNR017228}.
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DR   AlphaFoldDB; A0A1I8EFQ1; -.
DR   STRING; 6293.A0A1I8EFQ1; -.
DR   WBParaSite; maker-PairedContig_1872-snap-gene-0.9-mRNA-1; maker-PairedContig_1872-snap-gene-0.9-mRNA-1; maker-PairedContig_1872-snap-gene-0.9.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042284; F:sphingolipid delta-4 desaturase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030148; P:sphingolipid biosynthetic process; IEA:InterPro.
DR   CDD; cd03508; Delta4-sphingolipid-FADS-like; 1.
DR   InterPro; IPR011388; DES1/DES2.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   InterPro; IPR013866; Sphingolipid_d4-desaturase_N.
DR   PANTHER; PTHR12879; SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2; 1.
DR   PANTHER; PTHR12879:SF8; SPHINGOLIPID DELTA(4)-DESATURASE DES1; 1.
DR   Pfam; PF00487; FA_desaturase; 1.
DR   Pfam; PF08557; Lipid_DES; 1.
DR   PIRSF; PIRSF017228; Sphnglp_dlt4_des; 1.
DR   SMART; SM01269; Lipid_DES; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|PIRNR:PIRNR017228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR017228};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR017228};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          37..75
FT                   /note="Sphingolipid delta4-desaturase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01269"
SQ   SEQUENCE   375 AA;  43665 MW;  BA9640D7CE4AA234 CRC64;
     LVSLIFVRCF VQKKNTCFFK NLLKTSLRSK LLVMHGVDVQ DFGWSYTEEP HASRRNEIIQ
     KYPEIKKYFG VDPSFKYVVL AMVLAQFSIA WLLRDSDWLL ICLQAYCTGG TVGHSLTLAV
     HEISHNMAFG CAHPLANRFF GFIANLPMMV PMSVSFKKYH LEHHRYMGEE VLDTDIPTNF
     ETRYFRRTLG KLLWVFLQPF FYASRPFLIY PKAVTDLEIL NALLQIFTDY IVIRFFGWKA
     FAYLLGGFFV GSGIHPLASH YISDHYVFNP GQETYSYYGP INLVTFNVGY HIEHHDFPYV
     CGSNLPKISA LAPEYYKDYM VHSSWIYMMY DFITNPKMSL YSRTKRKMAK PTDVHFFDTG
     PNTSCFIYKF FSSVS
//