ID   A0A1I8EFV5_WUCBA        Unreviewed;       958 AA.
AC   A0A1I8EFV5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=EGF-like domain-containing protein {ECO:0000259|SMART:SM00181};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_1905-snap-gene-0.22-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-PairedContig_1905-snap-gene-0.22-mRNA-1}
RP   IDENTIFICATION.
RC   STRAIN=pt0022
RC   {ECO:0000313|WBParaSite:maker-PairedContig_1905-snap-gene-0.22-mRNA-1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I8EFV5; -.
DR   STRING; 6293.A0A1I8EFV5; -.
DR   WBParaSite; maker-PairedContig_1905-snap-gene-0.22-mRNA-1; maker-PairedContig_1905-snap-gene-0.22-mRNA-1; maker-PairedContig_1905-snap-gene-0.22.
DR   CDD; cd19941; TIL; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR   PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR   Pfam; PF14670; FXa_inhibition; 2.
DR   Pfam; PF00058; Ldl_recept_b; 1.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00135; LY; 8.
DR   SUPFAM; SSF57196; EGF/Laminin; 2.
DR   SUPFAM; SSF63825; YWTD domain; 3.
DR   PROSITE; PS51120; LDLRB; 3.
PE   4: Predicted;
FT   DOMAIN          345..384
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|SMART:SM00181"
FT   REPEAT          481..523
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          524..569
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          570..612
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   DOMAIN          668..706
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|SMART:SM00181"
SQ   SEQUENCE   958 AA;  107003 MW;  B0D846EEA03F0710 CRC64;
     MKANLFTIAM CYALIERAVL TKVPVLARQR KTITQLTLDV DKTMITSATE IVSGIDESFP
     VLIALDVNRN ILAYMESWQR SSSGNIRVIA LDNSTVPAYI HRSSGVTEET VTSLAIDWVT
     GKLYVGVETA SIHNAGRIEV CPLDGQTTCA IVLHSSFENQ DSRVDALHSL VLDPVDGYMY
     WLNRVHKRIE RAWMDGRHHD PHCFKDDTTG VVATSALTLE QVSRMLYYVR TRTSLDESQI
     WSCSLYDRES CRAVASKVNA FYLDVFSVES CGRKPKILAL MSLFKKNIIK AYLIWSSVTN
     QNSGITVCEK MDCDRTIREM VNSSGVEALV VFDEQVQPLK QSLNPCGSKN GGCSHICVLI
     PGAPWRSCLC PVGVRLLQDR LTCSPNGIES LLYVATTSGL IFISLDTAHH TPLPLPNVAS
     EIRDTKVVHI DFDPIDKKLF MIDGDMGVIR RCNPDGTGME VFVEDSDKLA SDALAVDWLN
     RNLYWLDSNV AQIKMQSLSS KGRQIVISHG LKQPRGLALD PDGGYMFFSD WHESTSRIEK
     AWLDGSHRRV LVSLEKNTWP NGIVVDARHK RLYWAEGSRS FIKSVAVDGK LDVQVFAESV
     NHPYSLTILG NSLYCNSLYG RKISVFRVPR HNESFLDVQL SVVSDSVIFG QMGIRAVSLN
     HIPEGVSPCQ TSNGGCSHIC VKLPSGKRGC VCPVGYELQA DNTTCILPAA FLIYTQSPAV
     NTANNIMRIS LETAPANNHL INIADMTSAP VSVDINQNSQ RIFWSSEGRG RSIRSLLRSA
     FFNGSGLKTV YEGNAVNYIA VDWITSNIYW LDIVLRCNME QRRIEMVRGD GRRHRTIAWE
     NIDPRYLVVH PLQRFLVFVN YYNQQKITIN KIPLHGEQSG GQVIVQQLDT VNALAIDFES
     ELLVWSELDE HGGGVSISDF SGLFFGLPDR DVRFWILGFT VSSEANSFRH KKSEFIFS
//