ID A0A1I8EH76_WUCBA Unreviewed; 1974 AA.
AC A0A1I8EH76;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_206-snap-gene-3.19-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-PairedContig_206-snap-gene-3.19-mRNA-1}
RP IDENTIFICATION.
RC STRAIN=pt0022
RC {ECO:0000313|WBParaSite:maker-PairedContig_206-snap-gene-3.19-mRNA-1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR STRING; 6293.A0A1I8EH76; -.
DR WBParaSite; maker-PairedContig_206-snap-gene-3.19-mRNA-1; maker-PairedContig_206-snap-gene-3.19-mRNA-1; maker-PairedContig_206-snap-gene-3.19.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 3.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1974
FT /note="1-phosphatidylinositol 4-kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009318188"
FT DOMAIN 1408..1583
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1684..1958
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1974 AA; 223938 MW; EDA0C693CD4AFA8A CRC64;
MIMLRSYLMR IVCFMIGLLR SFGRYSGDKD HPLISAIYPI PFIITKIDVH SNQTTECNRA
GTLRLTTDSE NFLWSDAANT EKQDQKERLQ KMFSKHASSF VLPTVFNDSI PKFKFTIAEL
NSFSNIMERL LRRPLLDIMD AYATDVYMAG QIKRFPYKTL SECLSLVFVT AYRDAYAPYD
MLKLEKSLAE KLSREVKAFA IELYSKGEDF LNVQKLNDDE RTLRCPLLIN RIKMSVLCSS
VCLELMVWAT CDEIDAESLH ATIADRLWHV HGHRHASAKI SLTMMALEAL GSLAVKFPTI
AATLAVNSVS QFLVEPSPVL SKLAIDLGVI LLQIMEKRVF SEGDRKDGEM ESRNKLALQS
TKIGHDSRQF ICTSLSNKYL LQTILDCEQR LKLDKSEPFT FSGSALALEN AMHIVGGIGA
ALVDVENVPQ LAFSVFQQAF AETSTNHDVI VAELANMWIA GARDIHDLIW LLFTKITIES
SSRAYDADTA DGVEHRYAYL SLAVDNAMAK MAESVNNDED KMTLLYRLLE LFVQLGHEGR
KAGEKLAKVM KLSTGAGNLG VLIPKIASLL RRSVAIKNPS VRLRNLFRDF WFCCTVLGFN
VARIGLWPEE WFEAACEIAC KSPILIPQES LRAELVANAT IKSGSVLSVG FKYNSVLFEL
SVAELQEIRV TILSEISPSP EVTAVINKLE FTHCIYLLSV FRMELMRALH SVEPGAVHSI
FQYLEDKSIR KDKDGIWTCL LAAARTIFSK YLKVASERNL DSAHERQLEL HAQFLLIMFN
HHLKEANIFE EILLYRDTCL TNLIGSFPHL LWNGNVINVA LQMLEALSNN LENDTDCKIM
TLSFPSLQRS IQLQDTLDRR KLVVQDFALR CEQILQEAIK WAPGITRSCF IKYIASINPG
CSGSFRLTVE AILKSLNDVS GCTNDTSPSL YLSALHLRSL YFGKVKGMIE ASKTEEETKP
HEQLADLFEQ QLERACADGC DREISECVLR LAALFILTKE VSNQKLDSSL LHTLVFTPLK
NFTASTMRLC VIVWNWILVA REDTQLQFLR EMAACWTVTA QDHLGIFERD PEVVSPLSLQ
YCSPPKRPHI LPHSIWIYFL VERVDIAKYS SREQLDILEL MFVQTLPLNV GRLRIDVNSP
LCISSDLSLC KVDLTHVTMT RNVETIGLRC HFLNCVLSMI QRDSMSFHIS KNILRQRVYC
AMLDYFSYVV LFYKLSELQM LKFLIFLSGC SVAAQTPTQN AAQLKNDIRL LITFWNTLFS
DVKYIKKEIF ASIDTELNLE SLQQILNDNY KSDSEYNRAD MQTHHAMTTS GCNWVTLVAA
QGRASSLQKN TLTVDPSRSS PNKHAEQQMK LYNRYRNLIL IFVVGANEIE RLSAWLNPLG
EALGLEDASI EQWRKSTFPD ARTEAKLLRE NVRIAWQICP DLAVFRSCSA CQTAVQELLV
NSPELVMDLP EALSLMLGEG RILEEKVEDL KILSHILTWA ICDPVMALSL LGPRQYPAHP
ITVQYAVRVL RSYPPDVLLL YIPQLVQALR HDTMGYVAEL IMWLAGHSQL LAHQLLWNMK
ANMYRDEDSR EKDPDLHGPL SELINKIISN MEGAARKFYD SEFDLFKHIT DISGKIRLFP
KGEARKKACL TALAEIHLKT VAYLPSNPEA IVLDIDYKSG TPMQSAAKAP FLARFKVLRC
GIQKLEQLGI AAHQRKHIPE ADIRFLSRSE DSLVCWQAAI FKVGDDVRQD MLALQLMSLM
RNIFNSVNLD IRLFPYRVVA TGPGCGVIEC VPNSKSRDQL GRQTDFGLYE YFLTTYGDEN
TETLQRARRN FIRSMAAYSV FSFLLQIKDR HNGNIMIDTD GHIVHIDFGF MFESSPGGNL
GFEPDFKLSQ EMVAIMGGKM EAPSFRLFAS LCVQAYLAVR PYYKAFIALV SLMLDTHLPC
FRGKTIQQFR DRFAPQLSDR DAAKYMMSII RNCFLNVRSK MYDQLQYIQN EIPY
//
