ID   A0A1I8EIG4_WUCBA        Unreviewed;       919 AA.
AC   A0A1I8EIG4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_2158-snap-gene-2.38-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-PairedContig_2158-snap-gene-2.38-mRNA-1}
RP   IDENTIFICATION.
RC   STRAIN=pt0022
RC   {ECO:0000313|WBParaSite:maker-PairedContig_2158-snap-gene-2.38-mRNA-1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; A0A1I8EIG4; -.
DR   STRING; 6293.A0A1I8EIG4; -.
DR   WBParaSite; maker-PairedContig_2158-snap-gene-2.38-mRNA-1; maker-PairedContig_2158-snap-gene-2.38-mRNA-1; maker-PairedContig_2158-snap-gene-2.38.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        466..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        511..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        599..619
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        631..651
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        720..739
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        846..871
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          51..128
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   919 AA;  105712 MW;  5269FFD014961B1B CRC64;
     MESLYRSEEM CLAQLFLQTE AAYTCVAELG ELGLVQFRDL NPDVSAFQRK FVNEVRRCDE
     MERKLRFLER EIKKDLIPML DTGENPDAPQ PKEMIDLEAT FDKLENELQE VNQNEEMLKK
     NFSELMELKH ILRKTQQFFE EVEYGRWPYA KQEENQHCFI REEEQNLLSE SRSVAAGAET
     IVPPNAPIGT GLPEQIVLQE TEGIGIELSG AGVTGQMFAN FGFVAGVIER ERLPAFERLL
     WRACRGNVFL RQSEIAEPLI DSTTVNHYFH FLPSYGDPII NTVFIIFFQG DQLKTRVKKI
     CEGFRATLYP CPDTPQERRE MSIGVMTRIE DLKTVLGQTQ DHRHRVLVAA SKNVRMWLTK
     VRKIKSIYHT LNLFNLDVTQ KCLIAECWCP VADLSRIQLA LKRGTEESGS TVPSILNRMS
     GITEAPPTFH RVNKFTRGFQ NIVDAYGIAS YREINPAPYT MITFPFIFAV MFGDCGHGLI
     MLLCALFFIY REKQLEAARI NDEIFQTFFN GRYVIFLMGC FSVYTGFIYN DAYSKSFNLF
     GSSWRNIYAD LSKYESEKEL MLTPQWAYYN LSIGPYPIGV DPIWNLAESN KLNFLNSMKM
     KMSIIIGVAQ MTFGVMLSYE NYKYFGSRLD ILYMFIPQML FLGCIFIYLC LEILFKWLLF
     SAKSGYVLGY EYPSSNCAPS LLIGFISMFM MKHRPSGFLD PEGNVYPQCY LNLWYPGQSF
     FETLFVLLAA ACIPIMLFGK PYMQWKEFKE RATLGSSNLS VRAESNGDDA HIIHNDLSRS
     STTHIEEKFD FADVMVYQAI HTIEFALGCI SHTASYLRLW ALSLAHAQLS DVLWTMVFRQ
     AFMLNGYMGA VATYVLFFLF ASLSFSILVL MEGLSAFLHA LRLHWVEFQS KFYKGLGYAF
     VPFSFDKILE EARTAEENI
//