ID A0A1I8EIK8_WUCBA Unreviewed; 891 AA.
AC A0A1I8EIK8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RhoGAP domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_2307-snap-gene-3.21-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-PairedContig_2307-snap-gene-3.21-mRNA-1}
RP IDENTIFICATION.
RC STRAIN=pt0022
RC {ECO:0000313|WBParaSite:maker-PairedContig_2307-snap-gene-3.21-mRNA-1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR AlphaFoldDB; A0A1I8EIK8; -.
DR STRING; 6293.A0A1I8EIK8; -.
DR WBParaSite; maker-PairedContig_2307-snap-gene-3.21-mRNA-1; maker-PairedContig_2307-snap-gene-3.21-mRNA-1; maker-PairedContig_2307-snap-gene-3.21.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF10; GTPASE-ACTIVATING PROTEIN CDGAPR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 190..269
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 341..537
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 35..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..846
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 891 AA; 100025 MW; 0399C06AF272FFFF CRC64;
MVEKVTAPET KIATTISNNI RNNIFGHISP LVGRNNNSNH CSSPKNNSTT VKRSSSIKKL
IDQDHFHYEK VELGSIGVTL IAYEPNASSS TEQLRLQIES AGQKWCINRS IDQLCEFDHQ
LHRCSHLKEL ALELKQCDPK NAQRQIHIYL QQLSHITGNL MCCYSVLKFL EVDSHGNRFL
AAEETPINTP AIASAVVTKD FKAETGDQIS LRVGDIVSII EKVTPFSNKD KSWWKAKLTI
AKNENGKIIL GRKFEVGLFP SECVKIFDDK TGPSADQQLL SSKKGALVTP INGHTFLKPT
TNLTSPSKKS TGCHPPRRDR SLVRTLLRRH AERQTPLVFG TDLVEYLQKT GEDVPLILKK
CVEVIEMHGI VTGVYRQCGI QSNIQKLRND FDSGHLPDLR DEAILKDIHS VSSLLKQYFR
QLPNPLFTFE LYPEFIGAYE TTDDEQANRF KDVIGRLPRE HYRTAKYLIR HLTKLCQCTH
LTDMNSKNLA IVWAPNLFRC PPCVDDNFGG SDSSLLQGLN AQTGLCNYIL AHAVYLFSLE
NDSLSLPENA ISRSSVSSCS GGTLSPDLDR RRFIDVNGGP ATLPTFHTII EKPRHRETST
HPGSKWRRML RGPSMDNAFA SLRTRWKKHG EAYLDNDNST NSVKWRRSPS DTRASLRAAR
SASLISFVTK SVEEFRNGVL RSWRHCAPTL RDDSITNGTS EEQHSTATAV ATELVRRRGL
TSFLANDQQP STSTDTKLAS SIRGSIPEAF SLDTSDSGNS RPPSITQNDC IDDGVSLSSD
SYRFFGFYED EQQSEEGVNL RDIKEIWTKD SAESEHNSHV AFNMKTTSSK KNLSRNETED
NLRSSSTDEW SDVVKSENAG EGRYVETPLS FYDLPQNSVK PVRSNVQLYF F
//
