ID   A0A1I8EKN5_WUCBA        Unreviewed;      1038 AA.
AC   A0A1I8EKN5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=USP domain-containing protein {ECO:0000313|WBParaSite:maker-PairedContig_2580-snap-gene-2.17-mRNA-1};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_2580-snap-gene-2.17-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-PairedContig_2580-snap-gene-2.17-mRNA-1}
RP   IDENTIFICATION.
RC   STRAIN=pt0022
RC   {ECO:0000313|WBParaSite:maker-PairedContig_2580-snap-gene-2.17-mRNA-1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A1I8EKN5; -.
DR   STRING; 6293.A0A1I8EKN5; -.
DR   WBParaSite; maker-PairedContig_2580-snap-gene-2.17-mRNA-1; maker-PairedContig_2580-snap-gene-2.17-mRNA-1; maker-PairedContig_2580-snap-gene-2.17.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR048841; PAN2_N.
DR   InterPro; IPR028881; PAN2_UCH_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR15728; DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2; 1.
DR   PANTHER; PTHR15728:SF0; PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2; 1.
DR   Pfam; PF20770; PAN2_N; 1.
DR   Pfam; PF13423; UCH_1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   4: Predicted;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022839};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722}.
FT   DOMAIN          476..836
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
SQ   SEQUENCE   1038 AA;  117113 MW;  5184DCE8795D9F5A CRC64;
     MRMYGSSPGH SENVLISADG LTSMNNEARI PEGGFALLST TSQNAALAHF ITALTFDPYQ
     ELLWTGNNTG RVVSFYGAQL DKYTAFLSAT NSNIRALLAS ETVIFSLTSK RLRANRRQGI
     SLFTHTSDHT TDLTCMHRLS DVPHKLLLGG NQQQIIQFDV SVKQKNCLAL RSNQKFLFSS
     DSEGNVTLRH LTTVDAIHAL QAHQGSIADF DVCGNKLITC GYSPRMGKMA GDRFIMIYDL
     RTLRSLPPVP LPMAPSYCRF LPSYSDGRIM VCSQSGELII MDLNEQSSQM PIQLDTNGFA
     ITSLDVSTSK QCICFGDQTG LIHLFSDRME PIFNENSWGT DFPDPIAFHP PVSIDDPEPS
     YGVFPLPFPM DDHYASDWPE QLCIRRFRQP DPISEKVIDS MRMVQFVGYA HNPRAGTSLR
     GFNVCPYTTS THDKCSNAMK NDDLLHIPKF YLRTEGRLTS KAEEIDFKRY NRTEFNALEN
     SVETSPACML LLAMYHLMNV RTVFLSHFCY LEGCISCEMN LLFRLLTDRP VSSVVSAKNF
     MKTFRSVDDG KKWADAVANA SLAQTVRLFM QAFSKILDKE LSETTAGVAL RKEMEISFTL
     NNHCIRCSEH YQSALSQLYI SLAYPTNNEK IGFCTLLEKT LNCPEQNEAI CQKCGKLARF
     ASTRRVRLLP NILALDMTAS TETEQAFWIS HIQAFESRTV PNSVTEHKVK LCRYGTECRN
     PNCRKCETNV LATEGITTCY ECPHYIPNSV HIKITDGICT NKMENSTSFH LVAAIFIINE
     DKETETEEHL VTVIRSKQDS CWILFNSWSV TRISENEALR LHACWKLPAI LYYVQDRENG
     GKEAAENENR AIIPRSVFWN DLDSNKIKIP ERESKVAIYA KYAISEAGEK RVSEVSAVDE
     DGSCFISSVI KEPGVKSDMD NSQTLKRVSL KLLYLIQEKI TIIGYKIEHL FEMLNIHVSE
     EQAKDIVLLY RSLFKRSLSL NALAQHFFGE SVDEEETDPV DLARLSLRLY TKFNELKEAD
     EADISSTVLT HALETNIS
//