ID   A0A1I8ESE3_WUCBA        Unreviewed;       678 AA.
AC   A0A1I8ESE3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_4586-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-PairedContig_4586-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RC   STRAIN=pt0022
RC   {ECO:0000313|WBParaSite:maker-PairedContig_4586-snap-gene-0.2-mRNA-1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001436,
CC         ECO:0000256|RuleBase:RU003431};
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A1I8ESE3; -.
DR   STRING; 6293.A0A1I8ESE3; -.
DR   WBParaSite; maker-PairedContig_4586-snap-gene-0.2-mRNA-1; maker-PairedContig_4586-snap-gene-0.2-mRNA-1; maker-PairedContig_4586-snap-gene-0.2.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF494; GUANYLATE CYCLASE; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          180..466
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          489..618
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          136..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   678 AA;  77462 MW;  580960F1EB468063 CRC64;
     MSWKIRWEDL DGDELKKDKK KSRRIRRLHG FNFESEALLR SYSRTSNGSE NFDEDEREFS
     IGRFRLRSTS SNATRKFSAL IDRKLSMFTR KKNSNQQDST HMVQNHISKD FVHKMDAIAR
     SGQYATISEG IESKDYDTVE GSEIPSPLSS ISNPKRKSPG EDDFDLHAKK SLSLRNRKLS
     FAGFSIGSGG SVETIQMQNN VQIYTKTANY KGTIVAVKNL NIDPKKYPKL DLTRSMLMEF
     KRIKDLQHDH ITRFTGACVD CPHYCLVQEY CPKGSLEDIL ENEKIELDKM MKYSLLHDLV
     KGMYFLHNTF VGSHGKLKSS NCVVDSRFVL KVTDFGFHEL HAMEDESTEE IGEHAFYKRK
     LWTAPEILRN PTAYRANGTK AGDAYSFAII LHEICWAEEF HERPDFAVIR KVVRSLNKSN
     ETSNVVDNLL KRMEQYANNL EGLVEERTQE YLAEKQKVED LLHQLLPRSV ADQLISGRAV
     QAEAFESVTI YFSDIVGFTA LSSMSTPMQV VTLLNDLYMA FDGVVDNFKV YKVETIGDAY
     MVVSGLPERH NHHASQIAQM SLALLHKVKN FVIRHRPNEQ LKLRIGIHSG PVVAGVVGCK
     MPRYCLFGDT VNTSSRMEST ALRIHVSSHT KTILNREDPG FQLVLRGEVE MKGKGKQITY
     WLKGYNDIRI PDFGPEFE
//