ID   A0A1I8ETD0_WUCBA        Unreviewed;       677 AA.
AC   A0A1I8ETD0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Nuclear hormone receptor {ECO:0000313|WBParaSite:maker-PairedContig_4947-snap-gene-0.6-mRNA-1};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_4947-snap-gene-0.6-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-PairedContig_4947-snap-gene-0.6-mRNA-1}
RP   IDENTIFICATION.
RC   STRAIN=pt0022
RC   {ECO:0000313|WBParaSite:maker-PairedContig_4947-snap-gene-0.6-mRNA-1};
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000256|ARBA:ARBA00005993}.
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DR   AlphaFoldDB; A0A1I8ETD0; -.
DR   STRING; 6293.A0A1I8ETD0; -.
DR   WBParaSite; maker-PairedContig_4947-snap-gene-0.6-mRNA-1; maker-PairedContig_4947-snap-gene-0.6-mRNA-1; maker-PairedContig_4947-snap-gene-0.6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24083:SF54; NUCLEAR HORMONE RECEPTOR HR78; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          191..266
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          373..649
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
FT   REGION          12..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   677 AA;  73055 MW;  4B9B1567395E27F7 CRC64;
     MDVLTLGGIS AVNSSNTESL PSPATSSPSQ SSEITKHHRH EDTVASTGLL RPYQKSDGAI
     PILSAFSART TSNPDQLQPP GIPITSFNPL LTPAMMAAQI GLLSAPNTLL SVMQAATAQN
     SLMHLNRCND RDGQMVPAML HQLSALHSNQ LMAAAASVHH SSAAGSVSRG GSASSPHCTS
     NASTAVRDMC VELCVVCGDK ASGRHYGAVS CEGCKGFFKR SIRKQIGYVC RGTKDCPVTK
     FHRNRCQYCR LRKCLTMGMR SESVQAERRP VGSASNSEAA PTMVATTSSA SIRPEALKTP
     PIVKHESAFM NGLLAIVRNE VANTELKQEP NETKNSETID ISPASPISVV QPASVSPRPQ
     SSIINEDKFG REDDETTVAA FLGAPLSTSP SSSGASSSLL EDGSLLNSER AKFELPVPQP
     MPSELNIQFI CETASRLLFL SVHWMKNFKA ISSNPGCLEQ LMKLKWCDLF ILGLMQCSNQ
     FCLSNMLAAM STHLSACSRI GQLKTERFEE VNEQIGYLFK LVQRFEELKL SSMEFAYLKL
     ISFTANDLPS SSTDASVRAI HAQALQELYE YILSLSITNC EDSASENDNT SGAAAASTVY
     NAIERYSHLL LLLPTMRWFK QAVLVELFFS GLIGSLSIET VMPFILAMDV MNVFDGSTGS
     DSLPGAQSLA NMFCKND
//