ID A0A1I8EW37_WUCBA Unreviewed; 345 AA.
AC A0A1I8EW37;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Guanine nucleotide-binding protein alpha-12 subunit {ECO:0008006|Google:ProtNLM};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_5808-snap-gene-0.5-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-PairedContig_5808-snap-gene-0.5-mRNA-1}
RP IDENTIFICATION.
RC STRAIN=pt0022
RC {ECO:0000313|WBParaSite:maker-PairedContig_5808-snap-gene-0.5-mRNA-1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR AlphaFoldDB; A0A1I8EW37; -.
DR STRING; 6293.A0A1I8EW37; -.
DR WBParaSite; maker-PairedContig_5808-snap-gene-0.5-mRNA-1; maker-PairedContig_5808-snap-gene-0.5-mRNA-1; maker-PairedContig_5808-snap-gene-0.5.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000469; Gprotein_alpha_12/13.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF362; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00440; GPROTEINA12.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 40999 MW; F16B6D9FF0667116 CRC64;
MLWKTYGRAD RNYRETTPKR KETTSSTGES GKSTFIKQMV IINGRGEFTA DEIRAYRQQI
YQNVIAAMRV LLDARQKLGY AWKNPERQKN VDCIMRFTVS DMMRGIDQST FAEIAPLIRD
FWEDASIKQT YEQRNLFQIS DSCIYFFDHI NRVAMPDYCP TNRDILFCRK ATRGITEHVF
EIQRISFRFI DVGGQRSQRQ KWFQCFEGIT SILFMVASCE YDQVILEDRR TNRVVESRSV
FETIANNKSF SNVSIILFMN KSDLLEEKVP KSDIRQYFAD FTGDHNSLRD VQFFLVDKFE
NCRRDRRRPF FYHFTTAIDT ENIRRVFKDC RETILEQNLK ALMMQ
//
