ID   A0A1I8F238_9PLAT        Unreviewed;       186 AA.
AC   A0A1I8F238;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=PDEase domain-containing protein {ECO:0000313|WBParaSite:maker-unitig_10071-snap-gene-0.1-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_10071-snap-gene-0.1-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-unitig_10071-snap-gene-0.1-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I8F238; -.
DR   WBParaSite; maker-unitig_10071-snap-gene-0.1-mRNA-1; maker-unitig_10071-snap-gene-0.1-mRNA-1; maker-unitig_10071-snap-gene-0.1.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR   InterPro; IPR023088; PDEase.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   PANTHER; PTHR11347; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; 1.
DR   PANTHER; PTHR11347:SF226; DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1; 1.
DR   Pfam; PF00233; PDEase_I; 1.
DR   PRINTS; PR00387; PDIESTERASE1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51845; PDEASE_I_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR623088-3}.
FT   DOMAIN          1..166
FT                   /note="PDEase"
FT                   /evidence="ECO:0000259|PROSITE:PS51845"
FT   BINDING         41
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
SQ   SEQUENCE   186 AA;  21526 MW;  D1B184B9FED8DB9A CRC64;
     MVLNTDMSLH FQQIKSMKQL LSMPDKIDKS KVLSMVLHCA DISHPGKPWE MHYKWTIALL
     EEFFRQGDRE KKLEIQVSPL CDRNTTLVAQ SQAGFIDFIM EPSFVVLGDM LEKILLPFFE
     QQQKQGDADS RDDEAEYDTK AMTLQRPWDS FIKENRAEWK VRAEKEEAEK KAKAAATEAE
     AADKKQ
//