ID   A0A1I8F3N8_9PLAT        Unreviewed;      1042 AA.
AC   A0A1I8F3N8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=TRPM1 {ECO:0000313|WBParaSite:maker-unitig_19331-snap-gene-0.2-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_19331-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-unitig_19331-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A1I8F3N8; -.
DR   WBParaSite; maker-unitig_19331-snap-gene-0.2-mRNA-1; maker-unitig_19331-snap-gene-0.2-mRNA-1; maker-unitig_19331-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR041491; TRPM_SLOG.
DR   PANTHER; PTHR13800:SF12; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2; 1.
DR   PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF18139; LSDAT_euk; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        413..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        489..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        527..550
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        562..580
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        600..623
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        680..704
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          14..74
FT                   /note="TRPM SLOG"
FT                   /evidence="ECO:0000259|Pfam:PF18139"
FT   DOMAIN          468..714
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          67..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          827..866
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          878..978
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        895..920
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        940..958
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1042 AA;  118059 MW;  2C76A59C45E8C0E3 CRC64;
     YGGSKSGVIK AKLQEQINQK EGISVVLLIV EGGLDIFEET QSMIQSNIPV VTCDNTGRAA
     DINRLRVQES TKSRQKDSVG EPTGGPSERM ISTFSENLKD PKTKKVNDKK VDENMSMLLE
     IVQKEKLITV DDLDLAILSA LLKVMDAKRL DDYKQQLQLS MTWNRPDIAA EKIFTEEHQW
     GTENLDKFAL SAISQEKIEF LRLFLKNGLI MREFLTVGRL RSLYRESLAA SSQASLQVRK
     LLAARTRAAG TRGSRPWRTF GMDKDVGTGG DDEQFERPFN QLFFWAVLLC KQDTAKFLWE
     RTDESVPLAL AASKVYNEMA RALSSHEDGR KRMLQAYKDE FEELAVHVVE ECQMVDPSKA
     ELLIEKKVEA FGDFNCLELA ASANCKKFVS CNSSQNSITS RWLNGLMHGT SNLRIFLCVV
     LPFLLPFEFL VRVEPSVRLD EGGRCAQLAH KVRIYYTAPV TKFFANAIWY VIFIFLYSWF
     ILFEMKAASI SWLEWVIIAW ICVMVVEEIR EMFSSKADTV QEKLRDWWGF SAWNRLDLFT
     MLLALIGIFL RIPEATDAIT TGVRTCYILA GVLFYLRAVY YANSYLGPKL VMIQKMVKEL
     LFYMSILIVA LVTYGVAAQA LLYPTRDFTT SIFVDIVYYP YWQIYGEIYL EVAEATPPEG
     CEDGSTVDSS GKLCPTHHSL VLLLLAVYLM VVNVLLINLL IAIFSNIFKE IQNNSVEIWK
     FNMYFLVHEY HTGPVLAVPF VIVEDVFRFI RFLACRLPCC RKGKEGESGR LSQREEADLR
     NFTTHCLSLV NTRQELETKG RIEQRIQSIY SGLDELYKMC DRIDERFDDE RHQGSGGGSG
     GGDREGSATS TKPRLPPAAG RRSCSGSVSA TSAAAIGLQQ KVTNRKDLGL PPIDPDARPQ
     TPKLQTEPPT PPPAPTPIGA APAPADEHQE VEAERKRQRR AEKERRRLER RMRRRSRSRH
     RPSDDEEERG AVGGGGFAYQ TLNDFNDFGA AEAGTEEERL VDMERRLRNM EAATTDSLGS
     IEKLLRQIVK DRSSKPDYAR LQ
//