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Database: UniProt
Entry: A0A1I8F4R8_9PLAT
LinkDB: A0A1I8F4R8_9PLAT
Original site: A0A1I8F4R8_9PLAT 
ID   A0A1I8F4R8_9PLAT        Unreviewed;       371 AA.
AC   A0A1I8F4R8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   08-MAY-2019, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|WBParaSite:maker-unitig_18713-snap-gene-0.1-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Platyhelminthes; Rhabditophora; Macrostomorpha;
OC   Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_18713-snap-gene-0.1-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_18713-snap-gene-0.1-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26392545; DOI=10.1073/pnas.1516718112;
RA   Wasik K., Gurtowski J., Zhou X., Ramos O.M., Delas M.J.,
RA   Battistoni G., El Demerdash O., Falciatori I., Vizoso D.B.,
RA   Smith A.D., Ladurner P., Scharer L., McCombie W.R., Hannon G.J.,
RA   Schatz M.;
RT   "Genome and transcriptome of the regeneration-competent flatworm,
RT   Macrostomum lignano.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:12462-12467(2015).
RN   [2] {ECO:0000313|WBParaSite:maker-unitig_18713-snap-gene-0.1-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   WBParaSite; maker-unitig_18713-snap-gene-0.1-mRNA-1; maker-unitig_18713-snap-gene-0.1-mRNA-1; maker-unitig_18713-snap-gene-0.1.
DR   Proteomes; UP000095280; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095280};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     60     83       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       29    155       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      162    332       IRK_C. {ECO:0000259|Pfam:PF17655}.
SQ   SEQUENCE   371 AA;  42491 MW;  E60DD057C7C4D2C8 CRC64;
     MEREYPKRKS STHPDRVGKR RRYKRLLFKN GDMNITQCSV KDRRRRYLAD IFTTLIDSKW
     TYAVLLFVAV FLVNCLIWLL VAFSRQDTIP EKADSARCVY GVSSFITAFQ FSLETQHTIG
     YGTPRTANSF CQRSVVGVLI QAFMTGFIFS KLTLPGKRAG AIMFSREALV TKRDDQMVLL
     IRVGDMRRSQ LMEASIKGTL VRKRITRENE ILPLEQFRVD FGASTGRDRL FLPFPAIVEH
     RIDEKSPFWD ISADDLQHEQ FELVVALAGV AESTGSTAEA RTSYLPSEIR WGYNFERLVT
     YQKENGRYQI DFNKFNSTRP TPLFPRMSAR QMAGLCEANL RLFDAPASAG SRISAIDETQ
     TVNPEEMDTH L
//
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