ID A0A1I8FD67_9PLAT Unreviewed; 879 AA.
AC A0A1I8FD67;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE SubName: Full=DNA_MISMATCH_REPAIR_2 domain-containing protein {ECO:0000313|WBParaSite:maker-unitig_30184-snap-gene-0.3-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_30184-snap-gene-0.3-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-unitig_30184-snap-gene-0.3-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR AlphaFoldDB; A0A1I8FD67; -.
DR WBParaSite; maker-unitig_30184-snap-gene-0.3-mRNA-1; maker-unitig_30184-snap-gene-0.3-mRNA-1; maker-unitig_30184-snap-gene-0.3.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF13768; VWA_3; 2.
DR SMART; SM00534; MUTSac; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 52..68
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 698..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..813
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..857
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 879 AA; 95139 MW; 3AE3332D46591C36 CRC64;
MAQIGCYVPA CSADISVLPG WRSRLTSTGR VHASWPRCLK LPAFCVRPRQ TSLVLMDELG
RGTSTYDGFG LAWAITQQLA NGLKCYCLCA THYHELAALA DLHSCVRNLC MSACVRDGRL
LLLYAVRDGV CDASLGLHVA KLAAFPSGTL RMAADKARDY DVFAASGKRS SSRARRGRRC
RRRSWRRSES SRLEDPADFD RLSPEERASR TRNLAVARYC LTYPKSRAVR GHSPRIVRVS
PPGRTPRLCS NSMPTVNDRL IQCEEFATNQ EAREAFRRAV QAGFSAAMAG ESDASSEQAG
SAVTIKMASL LELDRDRDWP VQDDHLCGNW CPGIRLDRRS ASRMCRPPTR PEMLVEAAVW
QPAVSGGGSS GWLSGRLSIE GQPDRPSPGQ SVECAQARRC LRPMILEIIL RYAERKAGRC
RSCWCRVSRF PTSQQQSVLR GCVLKCELML GEQLMSPRRD DSSASRRRSS SWFVDRSGSM
SGANIRAASE ACCCFLKSLP AGCLFKCDQL CSNFQPLFPT SQPYDGNSLD TALALQASLE
ANMGGTEILR PLQWLFGGGC DNTGACRVHT VGIGHGASTA LVKGVARVGR GQAEFVRDND
AAQLRRAVVT LDSRPLSFRT VPEDLSSLAP AMRIRIFVLL DVSDSSLSGS AGGLSVRAGL
SVGGVQHQLD CASVRLATGA ATVYQLAAAR HLIKEMVGRQ HSRRTNGGHS AAEGKATSLS
SPYTNFYWEW TALSGHAAEQ PKMPNDRQSG TGGTGLAYRY VVRYMGAAAT LCAPPPPPAA
NGRNDGLRKD GLRYGCTRLC PPPPPPPRAP PLPTRQRQMQ RGSCSIPIGS AVKSGAHVPA
PASQAPPPPP PPPPAAASFR GQQRAAGLKF QNCQGFRRA
//
