ID   A0A1I8FH99_9PLAT        Unreviewed;       448 AA.
AC   A0A1I8FH99;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000256|ARBA:ARBA00040215};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_34792-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-unitig_34792-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC       cotransporter that promotes absorption of the D isomers of essential
CC       amino acids. Neutral amino acids are the preferred substrates,
CC       especially methionine and phenylalanine.
CC       {ECO:0000256|ARBA:ARBA00037785}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A1I8FH99; -.
DR   WBParaSite; maker-unitig_34792-snap-gene-0.2-mRNA-1; maker-unitig_34792-snap-gene-0.2-mRNA-1; maker-unitig_34792-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616:SF241; SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED; 1.
DR   PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR   Pfam; PF00209; SNF; 2.
DR   SUPFAM; SSF161070; SNF-like; 2.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   4: Predicted;
KW   Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        38..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        222..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   448 AA;  51237 MW;  008F51A300C72AFD CRC64;
     MPAWPDCMAF LLGASSNDYM NYVAPARQAG QFPSHGPLRW DMSLCLLLAW IIVFLSLSKG
     IKSSGKVVYF TALFPYAVLI ILLIRGVTLP GCGNGLERRP SLHSLSPGAD EASRLPHSGR
     ILFFLMLIHS GLDSQFTCVE TAVTSILDRW PISDALQDTD DHDILHRGIF PRLVNVHPAL
     LTVFDDYSGA WKVMVITITG VRLHWLCLWS TKICQGRRAI DWSAYCWLPA MAATFALVVD
     GLLVLPDPRH CWGLFAWSAA SVWQMRSDPG QLIRPTRFWG PALVRFRREV TYVPGFEIDP
     WVGDNSNEHS NQAEKVEDEA TSHNFMCRSR SRLRRFSRCS RSHFSRLRLR DRLEPTPEPA
     LCLRRLRLYS LRRRSREIGL RCMKLQKPPR VHSPISYWRQ QASRKSVTGM VAEIVAHVHL
     FDFSVFLFGF NEHFFKEIVK KLLLLDFA
//