ID   A0A1I8FHH5_9PLAT        Unreviewed;       395 AA.
AC   A0A1I8FHH5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=HCO3_cotransp domain-containing protein {ECO:0000313|WBParaSite:maker-unitig_34925-snap-gene-0.2-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_34925-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-unitig_34925-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC       {ECO:0000256|ARBA:ARBA00010993}.
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DR   AlphaFoldDB; A0A1I8FHH5; -.
DR   WBParaSite; maker-unitig_34925-snap-gene-0.2-mRNA-1; maker-unitig_34925-snap-gene-0.2-mRNA-1; maker-unitig_34925-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR   GO; GO:0006820; P:monoatomic anion transport; IEA:InterPro.
DR   Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR   InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR   InterPro; IPR003020; HCO3_transpt_euk.
DR   InterPro; IPR016152; PTrfase/Anion_transptr.
DR   PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR   PANTHER; PTHR11453:SF82; SOLUTE CARRIER FAMILY 4 MEMBER 11; 1.
DR   Pfam; PF00955; HCO3_cotransp; 1.
DR   SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        345..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          318..390
FT                   /note="Bicarbonate transporter-like transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF00955"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   395 AA;  43247 MW;  4E8E24E24C5F0AA9 CRC64;
     PTRHRRCAAP SAARSPRDSG IAEAAPSRPS SASHAILAAA AAGLLMAAGA DGAARQQQGI
     RFDIRAGRAQ NFPLKDFSSE IRANMDIQRF LKEATLLLDV EGANVECIIE QMLRSIFRAD
     HESHHSSGSG GGGGDGGSVA GAAGAIDSRL DAKVQDAKKT CFCRLTGWTT PRLAKTIKSI
     SVVDSEGLIT DNSWLCTMCS LNGVQKRHVA IARLSTPVNL GRSSEGVSFI LLVVTPTKEK
     GTKSDIELGR TFATILADSE FRQKLLLAET ESEFKEMLQG HAHELGEEQK IYRRKSLRTK
     DFMSQAFNYL AHLQWHPSDL KRRLSHYLLS DFIDAFRDNK TIRKVVTTVI FLYFACLMPC
     IAFGVLNNSL TNGYISESFG LFAFQFVRTL FLSLS
//