ID   A0A1I8FJN1_9PLAT        Unreviewed;       408 AA.
AC   A0A1I8FJN1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Acetyl-CoA hydrolase {ECO:0000256|ARBA:ARBA00017958};
DE            EC=3.1.2.1 {ECO:0000256|ARBA:ARBA00011920};
DE   AltName: Full=Acetyl-CoA deacylase {ECO:0000256|ARBA:ARBA00029672};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_37157-snap-gene-0.1-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-unitig_37157-snap-gene-0.1-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001831};
CC   -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC       {ECO:0000256|ARBA:ARBA00009632}.
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DR   AlphaFoldDB; A0A1I8FJN1; -.
DR   WBParaSite; maker-unitig_37157-snap-gene-0.1-mRNA-1; maker-unitig_37157-snap-gene-0.1-mRNA-1; maker-unitig_37157-snap-gene-0.1.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IEA:InterPro.
DR   GO; GO:0003986; F:acetyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR   Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR   Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR   InterPro; IPR026888; AcetylCoA_hyd_C.
DR   InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR   InterPro; IPR046433; ActCoA_hydro.
DR   InterPro; IPR003702; ActCoA_hydro_N.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR21432:SF20; ACETYL-COA HYDROLASE; 1.
DR   PANTHER; PTHR21432; ACETYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR   Pfam; PF02550; AcetylCoA_hydro; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE   3: Inferred from homology;
FT   DOMAIN          51..191
FT                   /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02550"
FT   DOMAIN          283..381
FT                   /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13336"
FT   REGION          384..408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   408 AA;  44432 MW;  6E0B5C20B16F52D3 CRC64;
     MLLRVLPSTL SRCLRPVSRS YYVDQLSLGE PFHPVPNRHP VTMEAEKVFE QHLDSNQKVF
     VHGGAATPNH LIDSMVQVGL KRKLKNISVM HIHTEGPAAY NTEACQGVFR SNSLFTSANC
     REAIGAGRGD FTPIFLSEIP LLFRRGAVKL DLALIMVTPP DRHGFCSLGP SVDCARSAIQ
     NARVIVAQMQ QPLHEMPPKK INPQEQRIGQ LIAEKLVADG STLQTGIGSI PDAVLASLKG
     HKNLGVHTEM FSDGVVDLTE CGAVTNALKR IRPGKIVSGF VIGTKKVFDF IDENAMVELC
     DIHFVNKVAI IKPEIPGVTA PSIRSQRLDR TPRILLGRGR QIDFMRGAAL SSDGLGVPII
     ALQSSTKKGG SKIVPFIREG EAPPTLITTL PTSDHRESLE RPPQALAR
//